The effects of nicotine and sucrose on spatial memory and attention
The effects of nicotine and sucrose on spatial memory and attention
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DOI：
10.1080/10284150410001704543
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发表时间：
2004-04-01
影响因子：
3.6
通讯作者：
Kanarek, RB
中科院分区：
文献类型：
--
作者：
Harte, CB;Kanarek, RB
尼古丁和蔗糖都能提高认知任务的表现。然而，人们对尼古丁和蔗糖是否能共同作用来增强智力表现知之甚少。为了研究尼古丁和蔗糖对认知行为是否有相互作用，研究人员对14名健康吸烟者在连续表现任务（CPT）和空间记忆任务中的表现进行了测试，他们分别喝了8盎司含蔗糖或含阿斯巴甜的饮料，然后嚼了一块含2毫克尼古丁或不含尼古丁的口香糖。为了评估尼古丁和蔗糖摄入对情绪变化的影响，在每个测试阶段进行三次情绪状态谱（POMS）测试。与服用安慰剂口香糖的参与者相比，服用尼古丁的参与者在CPT测试中做出的正确回答明显更多，错误回答明显更少。对数据的进一步分析表明，蔗糖摄入量和尼古丁摄入量之间存在相互作用。当参与者喝含蔗糖的饮料时，尼古丁增加了命中率，减少了失球率，但当他们喝含阿斯巴甜的饮料时却没有。在整个实验过程中，尼古丁和蔗糖都没有影响空间记忆或情绪。然而，当对第一阶段的数据进行分析时，饮用含蔗糖饮料的参与者在空间记忆任务中的表现明显好于饮用含阿斯巴甜饮料的参与者。尼古丁或蔗糖对认知能力的影响没有发现性别差异。研究结果支持尼古丁和蔗糖对认知行为有积极影响，在某些条件下，两者对表现有叠加效应。
Both nicotine and sucrose can enhance performance on cognitive tasks. However, little is known about whether nicotine and sucrose could act jointly to augment mental performance. To investigate if there is an interaction between nicotine and sucrose on cognitive behavior, performance on a continuous performance task (CPT) and a spatial memory task was examined in 14 healthy smokers after they had drunk 8 oz of either a sucrose- or aspartame-containing beverage, and then chewed a piece of gum containing either 2 mg nicotine or no nicotine. To assess changes in mood as a function of nicotine and sucrose intake, the profile of mood states (POMS) test was administered three times during each test session. Participants made significantly more correct responses and significantly fewer incorrect responses on the CPT when they received nicotine than when they received the placebo gum. Closer analysis of the data revealed that there was an interaction between sucrose consumption and nicotine intake. Nicotine increased hits and decreased misses when participants were given the sucrose-containing beverage, but not when they were given the aspartame-containing beverage. Neither nicotine nor sucrose affected spatial memory or mood across experimental sessions. However, when data were analyzed for just the first session, participants who drank the sucrose-containing beverage performed significantly better on the spatial memory task than those who drank the aspartame-containing beverage. No gender differences in the effects of nicotine or sucrose on cognitive performance were detected. The results provide support that both nicotine and sucrose have positive effects on cognitive behavior, and that under some conditions the two variables have additive effects on performance.