Hormonal modulation of Schwann cell tumors. I. The effects of estradiol and tamoxifen on methylnitrosourea-induced rat Schwann cell tumors.
Hormonal modulation of Schwann cell tumors. I. The effects of estradiol and tamoxifen on methylnitrosourea-induced rat Schwann cell tumors.
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雪旺细胞肿瘤的激素调节。
DOI：
10.1111/j.1749-6632.1986.tb48090.x
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发表时间：
1986
影响因子：
5.2
通讯作者：
Martuza,RL
中科院分区：
文献类型：
--
作者：
Jay,JR;MacLaughlin,DT;Badger,TM;Miller,DC;Martuza,RL
雪旺细胞源性肿瘤是神经纤维瘤病（NF）最常见的重要临床表现。“先前的研究指出，神经纤维瘤可能在青春期和怀孕期间发展或扩大，听神经瘤和神经纤维瘤含有性类固醇激素的细胞质和核结合物。”3’~我们推测许旺细胞瘤的生长可能受激素调控。由于目前还没有自然产生的NF动物模型，我们研究了去势、17-6-雌二醇（Ez）和抗雌激素他莫昔芬对亲代给药n -甲基-n -亚硝基脲（MNU）诱导的大鼠雪旺细胞肿瘤的发生和生长的影响。
Tumors of Schwann cell origin represent the most common clinically important manifestation of neurofibromatosis (NF).'.'Prior studies have noted that neurofibromas may develop or enlarge during puberty and pregnancy and that acoustic neuromas and neurofibromas contain cytoplasmic and nuclear binders for sex steroid horm0nes. 3'~ We postulated that the growth of Schwann cell tumors could be modulated by hormonal rnanip~ lation.~ Since no naturally occurring animal model for NF is presently available, we studied the effects of castration, 17-6-estradiol (Ez), and the antiestrogen Tamoxifen on the onset and growth of Schwann cell tumors induced in rats by parental administration of N-methyl-N-nitrosourea (MNU).