ALTERATIONS OF MECHANICAL-PROPERTIES AND MORPHOLOGY IN EXCISED RABBIT LUNGS RINSED WITH A DETERGENT
ALTERATIONS OF MECHANICAL-PROPERTIES AND MORPHOLOGY IN EXCISED RABBIT LUNGS RINSED WITH A DETERGENT
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DOI：
10.1152/jappl.1979.47.5.1002
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发表时间：
1979-01-01
影响因子：
3.3
通讯作者：
WEIBEL, ER
中科院分区：
文献类型：
--
作者：
BACHOFEN, H;GEHR, P;WEIBEL, ER
为了评估肺表面活性剂的改变对周围空气空间几何形状的影响，研究了洗涤剂冲洗兔肺的形态学。与正常切除的兔肺相比，在放气压力-容积曲线的不同位置以相同的方式进行血管灌注固定，最重要的区别是：随着肺容量的减少，肺泡逐渐塌陷，在低肺容量（占肺活量的40%）时，大多数肺泡塌陷，空气被包含在过伸的导管中；肺泡表面积容积比相当小，特别是在中、低肺容积时；平均空气空间曲率在80%至40% TLC之间有轻微变化。显然，在用洗涤剂冲洗肺时，肺泡容量的变化主要是由肺泡的增加和减少引起的。在正常呼吸的肺容量范围内，似乎需要正常的表面活性剂和纤维连续体内的机械相互依赖。
To assess the influence of alterations of lung surfactant on the geometry of peripheral air spaces, the morphology of detergent-rinsed rabbit lungs was studied. Compared to normal excised rabbit lungs, fixed in the same manner by vascular perfusion at different points on the deflation pressure-volume curve, the most important differences are as follows: with decreasing lung volume there is a progressive collapse of alveoli, at low lung volume (40% of total lung capacity (TLC)) most alveoli are collapsed, and the air is contained in overextended ducts; the alveolar surface area-to-volume ratio is considerably smaller, particularly at medium and low lung volumes; there is a slight change of mean air-space curvature between 80 and 40% TLC. Apparently, in detergent-rinsed lungs volume changes are brought about predominantly by recruitment and derecruitment of alveoli. It appears that both a normal surfactant and the mechanical interdependence within the fibrous continuum are required to maintain a normal respiratory surface area within the lung volume range of normal breathing.