BRONCHIOLITIS OBLITERANS, BRONCHIECTASIS, AND OTHER SEQUELAE OF ADENOVIRUS TYPE-21 INFECTION IN YOUNG CHILDREN
BRONCHIOLITIS OBLITERANS, BRONCHIECTASIS, AND OTHER SEQUELAE OF ADENOVIRUS TYPE-21 INFECTION IN YOUNG CHILDREN
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DOI：
10.1136/jcp.24.1.72
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发表时间：
1971-01-01
影响因子：
3.4
通讯作者：
BECROFT, DMO
中科院分区：
文献类型：
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作者：
BECROFT, DMO
在明显由腺病毒21型引起的严重下呼吸道感染流行期间，在受影响的幼儿中观察到支气管扩张症和其他肺部后遗症的发生率非常高。描述了四例急性感染后每隔两个月至三年取一侧或双侧肺进行检查的组织病理学结果。广泛的细支气管炎闭塞(闭塞性细支气管炎)在所有四个病例中都是一个惊人的发现。支气管炎和支气管扩张症的严重程度与急性感染后的时间成正比。细支气管闭塞可能是坏死性毛细支气管炎的后遗症，坏死性毛细支气管炎可能发生在急性腺病毒感染期间。讨论了细支气管闭塞在支气管扩张症和其他慢性肺部疾病发病机制中的作用。腺病毒可能是儿童感染后支气管扩张的主要原因。
A remarkably high incidence of bronchiectasis and other pulmonary sequelae was observed in young children affected during an epidemic of severe lower respiratory tract infections apparently caused by adenovirus type 21. The histopathological findings are described in four cases in which one or both lungs were obtained for examination at intervals ranging from two months to three years after the acute infections. Widespread bronchiolar obliteration (bronchiolitis obliterans) was a striking finding in all four. The severity of bronchial inflammation and of bronchiectasis was proportional to the time elapsed since the acute infections. Bronchiolar obliteration is a likely sequel of the necrotizing bronchiolitis which may occur during acute adenovirus infections. The role of bronchiolar obliteration in the pathogenesis of bronchiectasis and other chronic lung disease is discussed. Adenoviruses may be a major cause of post-infectious bronchiectasis in childhood.