Clinical evaluation and symptoms of chemosensory impairment: One thousand consecutive cases from the Nasal Dysfunction Clinic in San Diego
Clinical evaluation and symptoms of chemosensory impairment: One thousand consecutive cases from the Nasal Dysfunction Clinic in San Diego
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DOI：
10.1177/194589240602000119
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Chen, M
中科院分区：
文献类型：
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作者：
Harris, R;Davidson, TM;Chen, M
背景资料：本研究的目的是测量嗅觉障碍的患者与各种病因使用症状评分和心理物理措施的嗅觉functions.Methods：我们进行了一个横断面，以人口为基础的研究，在鼻功能障碍诊所的加州大学，圣地亚哥（UCSD），医学中心。连续1000名患者到UCSD鼻功能障碍诊所进行化学感觉功能障碍的评估。结果：嗅觉障碍的程度与诊断类别、年龄、性别有关。病毒感染后紊乱在女性和老年人中更为普遍.老年人和20岁以下的患者表现出最高的头部外伤的发病率。总体而言，老年患者的阈值较差。男性表现出更高的发病率嗅觉损失继发于炎症和毒素暴露。患有炎症的患者比患有其他诊断的患者得分更高（即，先天性、头部创伤、病毒感染后、毒素暴露和其他原因）。先天性病因和头部外伤的患者得分最低。症状评分根据油诊断类别、年龄和性别而显著不同。炎症患者将大多数症状评定为最令人烦恼。病毒感染后诊断的患者最有可能报告副流感。患者头部创伤的评价味觉和嗅觉损失显着更严重的比其他patients.Conclusion：在圣地亚哥的UCSD鼻功能障碍诊所1.000例患者的评价显示差异嗅觉障碍和差异症状投诉的基础油诊断类别，年龄和性别。
Background: The aim of this study was to measure olfactory impairment in patients With various etiologies using symptom ratings and psychophysical measures of olfactory function.Methods: We performed a cross-sectional, population-based study at the Nasal Dysfunction Clinic of the University of California, San Diego (UCSD), Medical Center. One thousand consecutive patients presented to the UCSD Nasal Dysfunction Clinic for evaluation of chemosensory dysfunction. Olfactory impairment was assessed by odor threshold and odor identification and symptom scores were assessed by self-report.Results: The degree of olfactory impairment Was driven by diagnostic category, age, and gender. Postviral disturbance was more prevalent ill Women and among elderly people. Elderly people and patients under 20 years of age showed the highest incidence of head trauma. Overall, older patients had poorer thresholds. Men showed higher prevalence of olfactory loss secondary to inflammation and toxin exposure. Patients With inflammation scored better than patients With other diagnoses (i.e., congenital, head trauma, postviral, toxin exposure, and miscellaneous causes). Patients with congenital etiologies and head trauma had the poorest scores. Symptom ratings were significantly different depending oil diagnostic category, age, and gender. Patients With inflammation rated the majority of symptoms as most bothersome. Patients with postviral diagnoses were most likely to report parosmias. Patients With head trauma rated taste and smell loss as significantly more severe than other patients.Conclusion: Evaluation of 1.000 patients at the UCSD Nasal Dysfunction Clinic in San Diego revealed differential olfactory impairment and differential symptom complaints based oil diagnostic category, age, and gender.