Phosphate glasses for tissue engineering:: Part 1.: Processing and characterisation of a ternary-based P2O5-CaO-Na2O glass system
Phosphate glasses for tissue engineering:: Part 1.: Processing and characterisation of a ternary-based P2O5-CaO-Na2O glass system
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DOI：
10.1016/s0142-9612(03)00546-5
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发表时间：
2004-02-01
期刊：
影响因子：
14
通讯作者：
Knowles, JC
中科院分区：
文献类型：
--
作者：
Ahmed, I;Lewis, M;Knowles, JC
本文介绍了一系列磷酸盐玻璃的热性能、X 射线粉末衍射 (XRPD)、NMR 和溶解度的研究结果。还获得了离子释放和 pH 测量值。通过将 P(2)O(5) mol% 含量固定在 45、50 和 55 mol%，并将 CaO mol% 改变在 30、35 和 40 mol%，来限制成分。从热分析中收集的初始数据显示，正如预期的那样，T(g) 值随着 CaO mol% 的增加而增加。还观察到结晶温度随着 CaO mol% 的增加而增加，尖锐的峰表明单相和/或双相的存在。初始 XRPD 数据显示，45 mol% P(2)O(5) 在氧化钠含量为 25 和 20 mol% 时沉淀钙桥三偏磷酸盐 (Na(4)Ca[PO(3)](6))，但在 15 mol% 水平时形成两相：NaCa[PO(3)](3) 和 Ca(2)P(2)O(7)。 50 mol% P(2)O(5) 组合物显示出两个富含磷酸钠的相 [NaCa(PO(3))(3) 和 NaPO(3)]（对于含钙较低的组合物），以及对于具有较高 CaO mol% 的组合物的磷酸钙相 [CaP(2)O(6)]。 55mol％P(2)O(5)组合物对于含钙较低的组合物表现出相似的相，并且对于含钙较高的组合物鉴定出单一磷酸钙相(CaP(2)O(6))。 NMR 分析表明，45 mol% P(2)O(5) 组合物中存在 Q(1) 和 Q(2) 物质，50 mol% 和 55 mol% P(2)O(5) 组合物中存在 Q(2) 物质。从进行的热分析和溶解度分析获得的非线性数据归因于45mol％P(2)O(5)组合物的堆积密度。对于所有研究的玻璃，溶解度都随着 CaO mol% 的增加而降低，并且所有组合物都显示出 pH 值随时间逐渐降低，这是由于 Na(+) 和 Ca(2+) 离子释放到溶液中造成的。 (C) 2003 Elsevier Ltd. 保留所有权利。
This paper presents the results of a study of the thermal properties, X-ray powder diffraction (XRPD), NMR and solubility of a range of phosphate-based glasses. Ion release and pH measurements were also obtained. The compositions were limited by fixing the P(2)O(5) mol% content at 45, 50 and 55 mol%, and varying the CaO mol% at 30, 35 and 40 mol%. Initial data collected from thermal analysis showed an increase in the T(g) values, with increasing CaO mol%, as expected. An increase in crystallisation temperatures with increasing CaO mol% was also observed, with sharp peaks indicating the presence of single and/or double phases. Initial XRPD data revealed that the 45 mol% P(2)O(5) precipitated a calcium bridged trimetaphosphate (Na(4)Ca[PO(3)](6)) at the sodium oxide contents of 25 and 20 mol%, but at the 15 mol% level two phases formed, NaCa[PO(3)](3) and Ca(2)P(2)O(7). The 50 mol% P(2)O(5) compositions showed two sodium phosphate-rich phases [NaCa(PO(3))(3) and NaPO(3)] for the lower calcium containing compositions, and a calcium phosphate phase [CaP(2)O(6)] for compositions with higher CaO mol%. The 55 mol% P(2)O(5) compositions, exhibited similar phases for the lower calcium containing compositions, and a single calcium phosphate phase (CaP(2)O(6)) was identified for the higher calcium containing composition. NMR analysis revealed the presence of Q(1) and Q(2) species in the 45 mol% P(2)O(5) compositions, and Q(2) species present in the 50 and 55 mol% P(2)O(5) compositions. The non-linear data obtained from the thermal and solubility analyses conducted were attributed to the packing density of the 45 mol% P(2)O(5) compositions. The solubility was seen to decrease with increasing CaO mol%, for all the glasses investigated, and all the compositions showed a gradual decrease in pH with time, and this was accounted for by the release of Na(+) and Ca(2+) ions into solution. (C) 2003 Elsevier Ltd. All rights reserved.