Immunoglobulin isotypes in Atlantic salmon, Salmo salar.
Immunoglobulin isotypes in Atlantic salmon, Salmo salar.
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DOI：
10.3390/biom5010166
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发表时间：
2015-02-27
期刊：
影响因子：
5.5
通讯作者：
Hordvik I
中科院分区：
文献类型：
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作者：
Hordvik I
鲑鱼中有三种主要的免疫球蛋白(Ig)亚型：IgM、IGD和IGT，分别由重链μ，δ和τ定义。由于鲑科鱼类祖先的全基因组复制，大西洋鲑鱼(Salmo Salar)拥有两个高度相似的Ig重链基因复合体(A和B)，包括两个μ基因、两个δ基因、三个完整的τ基因和五个τ假基因。μA和μB基因对应于两个不同的血清免疫球蛋白M亚群。与IgM-A相比，IgM-B亚型在重链C末端附近有一个特征的额外半胱氨酸，并显示出更高的聚合物二硫键交联度。血清中的IgM-B和IgM-A的比例通常为60：40，但也可以观察到不对称的比例。在鲑鱼中，IGT同型似乎是粘膜免疫反应的特异体。血清中的IGT浓度比IgM低100~1000倍。已经在彩虹鲑鱼中发现了分泌形式的IGD，但在大西洋鲑鱼中尚未发现。
There are three major immunoglobulin (Ig) isotypes in salmonid fish: IgM, IgD and IgT, defined by the heavy chains μ, δ and τ, respectively. As a result of whole genome duplication in the ancestor of the salmonid fish family, Atlantic salmon (Salmo salar) possess two highly similar Ig heavy chain gene complexes (A and B), comprising two μ genes, two δ genes, three intact τ genes and five τ pseudogenes. The μA and μB genes correspond to two distinct sub-populations of serum IgM. The IgM-B sub-variant has a characteristic extra cysteine near the C-terminal part of the heavy chain and exhibits a higher degree of polymer disulfide cross-linking compared to IgM-A. The IgM-B:IgM-A ratio in serum is typically 60:40, but skewed ratios are also observed. The IgT isotype appears to be specialized to mucosal immune responses in salmonid fish. The concentration of IgT in serum is 100 to 1000 times lower than IgM. Secreted forms of IgD have been detected in rainbow trout, but not yet in Atlantic salmon.