Effects of low-level laser therapy (LLLT) on the nuclear factor (NF)-κB signaling pathway in traumatized muscle
Effects of low-level laser therapy (LLLT) on the nuclear factor (NF)-κB signaling pathway in traumatized muscle
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DOI：
10.1002/lsm.20371
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发表时间：
2006-08-01
影响因子：
2.4
通讯作者：
Gonzalez-Gallego, Javier
中科院分区：
文献类型：
--
作者：
Rizzi, Carem Fetter;Mauriz, Jose Luis;Gonzalez-Gallego, Javier
Background and Objective: To investigate the effects of low-level laser therapy (LLLT) on nuclear factor kappa B (NF-kappa B) activation and inducible nitric oxide synthase (iNOS) expression in an experimental model of muscle trauma.Study Design/Materials and Methods: Injury to the gastrocnemius muscle in the rat was produced by a single impact blunt trauma. A low-level galium arsenide (Ga-As) laser (904 nm, 45 mW, and 5 J/cm(2)) was applied for 35 seconds duration, continuously.Results: Histological abnormalities with increase in collagen concentration, and oxidative stress were observed after trauma. This was accompanied by activation of NF-kappa B and upregulation of iNOS expression, whereas protein concentration Of I kappa B alpha decreased. These effects were blocked by LLLT.Conclusion: LLLT reduced the inflammatory response induced by trauma and was able to block the effects of reactive oxygen species (ROS) release and the activation of NF-kappa B. The associated reduction of iNOS overexpression and collagen production suggest that the NF-kappa B pathway may be a signaling route involved in the pathogenesis of muscle trauma.
