Estimated Brain Tissue Response Following Impacts Associated With and Without Diagnosed Concussion.
Estimated Brain Tissue Response Following Impacts Associated With and Without Diagnosed Concussion.
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DOI：
10.1007/s10439-018-1999-5
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发表时间：
2018-06
影响因子：
3.8
通讯作者：
Greenwald RM
中科院分区：
文献类型：
--
作者：
Beckwith JG;Zhao W;Ji S;Ajamil AG;Bolander RP;Chu JJ;McAllister TW;Crisco JJ;Duma SM;Rowson S;Broglio SP;Guskiewicz KM;Mihalik JP;Anderson S;Schnebel B;Gunnar Brolinson P;Collins MW;Greenwald RM
头部撞击的运动学测量对运动冲击敏感，但特异性不高。一个潜在的原因是这些测量仅反映输入条件，并且可能与局部脑组织变形具有不同程度的相关性。在这项研究中，以前报道的头部撞击数据记录在外地从高中和大学的足球运动员进行了分析，使用两个有限元头部模型（FEHM）。45个与立即诊断的脑震荡相关的撞击被沿着模拟，532个控制撞击没有识别出脑震荡，这些撞击来自相同的球员。对于每次模拟，获得了全脑和四个感兴趣区域（ROI;大脑、小脑、脑干、胼胝体）的颅内反应测量值（最大主应变、应变率、von Mises应力和压力）。所有的反应措施诊断脑震荡敏感，但是，大的运动员之间的变异性观察和灵敏度强度取决于措施，投资回报率，和FEHM。有趣的是，峰值线性加速度比除压力外的所有颅内反应指标对诊断的脑震荡更敏感。这些研究结果表明FEHM可能提供独特的和潜在的重要信息的脑损伤机制，但在这项研究中评估的个人颅内反应措施的基础上，脑震荡风险的估计并没有改善那些来自输入运动学单独。
Kinematic measurements of head impacts are sensitive to sports concussion, but not highly specific. One potential reason is these measures reflect input conditions only and may have varying degrees of correlation to regional brain tissue deformation. In this study, previously reported head impact data recorded in the field from high school and collegiate football players were analyzed using two finite element head models (FEHM). Forty-five impacts associated with immediately diagnosed concussion were simulated along with 532 control impacts without identified concussion obtained from the same players. For each simulation, intracranial response measures (Max principal strain, strain rate, von Mises stress, and pressure) were obtained for the whole brain and within four regions of interest (ROI; Cerebrum, Cerebellum, Brain Stem, Corpus Callosum). All response measures were sensitive to diagnosed concussion; however, large inter-athlete variability was observed and sensitivity strength depended on measure, ROI, and FEHM. Interestingly, peak linear acceleration was more sensitive to diagnosed concussion than all intracranial response measures except pressure. These findings suggest FEHM may provide unique and potentially important information on brain injury mechanisms, but estimations of concussion risk based on individual intracranial response measures evaluated in this study did not improve upon those derived from input kinematics alone.
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影响因子：
4.1
作者：
Duhaime AC;Beckwith JG;Maerlender AC;McAllister TW;Crisco JJ;Duma SM;Brolinson PG;Rowson S;Flashman LA;Chu JJ;Greenwald RM
通讯作者：
Greenwald RM
影响因子：
3.8
作者：
Hernandez, Fidel;Wu, Lyndia C.;Yip, Michael C.;Laksari, Kaveh;Hoffman, Andrew R.;Lopez, Jaime R.;Grant, Gerald A.;Kleiven, Svein;Camarillo, David B.
通讯作者：
Camarillo, David B.
DOI：
10.1249/mss.0b013e3182793067
发表时间：
2013-04-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Beckwith, Jonathan G.;Greenwald, Richard M.;Collins, Michael W.
通讯作者：
Collins, Michael W.
影响因子：
3.8
作者：
McAllister, Thomas W.;Ford, James C.;Greenwald, Richard M.
通讯作者：
Greenwald, Richard M.
影响因子：
3.8
作者：
Beckwith, Jonathan G.;Greenwald, Richard M.;Chu, Jeffrey J.
通讯作者：
Chu, Jeffrey J.