Association between two SCN1A polymorphisms and resistance to sodium channel blocking AEDs: a meta-analysis
Association between two SCN1A polymorphisms and resistance to sodium channel blocking AEDs: a meta-analysis
复制标题
两种 SCN1A 多态性与钠通道阻断 AED 耐药性之间的关联：荟萃分析
DOI：
10.1007/s10072-018-3308-3
复制
发表时间：
2018-06-01
影响因子：
3.3
通讯作者：
Xiao, Zheng
中科院分区：
文献类型：
--
作者：
Bao, Yi;Liu, Xinzhu;Xiao, Zheng
钠通道阻断抗癫痫药物（SCB-AEDs）是治疗癫痫的常用有效药物。然而，并非所有患者都对该方案有反应，并且经常遇到耐药性。rs 2298771（c.3184A > G/p.Thr1067Ala）和rs3812718（IVS 5 N +5G> A）多态性是SCN 1A基因中最常见的两种多态性，与SCB-AED耐药密切相关。因此，我们进行了一项荟萃分析，以调查这两个多态性对SCB-AED耐药的贡献。检索了截至2017年9月的PubMed、Embase、MEDLINE和科克伦图书馆数据库，以查找SCN 1A多态性与SCB-AED耐药相关性的研究。根据异质性检验的结果，使用固定效应或随机效应模型计算合并比值比。共有8项研究符合汇总分析的条件，其中8项研究包括SCN 1A rs3812718多态性，4项研究包括SCN 1A rs 2298771多态性。结果表明，SCN 1A基因rs 2298771多态性与SCB-AED耐药显著相关。（A组与G组：OR = 0.76，95%CI 0.61- 0.95，P = 0.02; AA组与AG + GG组：OR = 0.71，95%CI 0.54- 0.94，P = 0.022）。然而，未观察到SCN 1A rs3812718多态性与SCB-AED耐药之间的关联。结果提示，SCN 1A rs 2298771多态性的A等位基因，尤其是AA基因型，可能在SCB-AED的疗效中起重要作用，而SCN 1A rs3812718多态性与SCB-AED的疗效无关。
Sodium channel blocking antiepileptic drugs (SCB-AEDs) are common effective medications available for epilepsy. However, not all patients respond to this regimen and drug resistance is frequently encountered. Rs2298771(c.3184A > G/p.Thr1067Ala) and rs3812718(IVS5N +5G > A) polymorphisms are two of the most common polymorphisms in the SCN1A gene, which is closely related to resistance to SCB-AEDs. Therefore, we have conducted a meta-analysis to investigate the contribution of the two polymorphisms to resistance of SCB-AEDs. The PubMed, Embase, MEDLINE, and Cochrane Library databases were searched up to September 2017, for studies on the association of SCN1A polymorphisms with resistance to SCB-AEDs. A fixed-effects or random-effects model was used to calculate the pooled odds ratios based on the results from the heterogeneity tests. A total of eight studies were eligible for the pooled analysis, of which eight studies included SCN1A rs3812718 polymorphism and four studies included SCN1A rs2298771 polymorphism. The results showed that SCN1A rs2298771 polymorphism was significantly associated with resistance to SCB-AEDs. (A vs. G: OR = 0.76, 95% CI 0.61–0.95,P= 0.02; AA vs. AG + GG: OR = 0.71, 95% CI 0.54–0.94,P= 0.022). However, no association was observed between SCN1A rs3812718 polymorphism and resistance to SCB-AEDs. Our results indicate that the A-allele of SCN1A rs2298771 polymorphism, especially AA genotype, may play an important role in responsiveness to SCB-AEDs, while SCN1A rs3812718 polymorphism is not associated with SCB-AEDs.