Shigellosis due to Shigella dysenteriae. 1. Relative importance of mucosal invasion versus toxin production in pathogenesis.
Shigellosis due to Shigella dysenteriae. 1. Relative importance of mucosal invasion versus toxin production in pathogenesis.
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由志贺氏菌引起的志贺氏菌病。
DOI：
10.1093/infdis/126.5.523
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
S. B. Formal
中科院分区：
文献类型：
--
作者：
P. Gemski;Akio Takeuchi;O. Washington;S. B. Formal
将能够穿透肠上皮细胞并产生毒素的志贺氏志贺氏菌 1 野生型菌株的致病能力与源自该菌株的三种突变体进行比较，这些突变体在这两种或其中一种细胞特性上都发生了改变。对几种动物模型（兔子、饥饿的豚鼠和猴子的回肠环）的研究结果表明，由不产毒的穿透性突变体引起的疾病与最初产生毒素的亲本菌株所引起的疾病不易区分。保留产生毒素能力的非穿透突变体和缺乏穿透和产生毒素能力的双突变体不会引起临床疾病。这些发现并不排除毒素在痢疾链球菌引起的痢疾发病机制中的作用，但表明在结肠粘膜中渗透和繁殖的能力对于引起疾病更为重要。
The disease-provoking capacity of a wild-type strain of Shigella dysenteriae 1 capable both of penetrating intestinal epithelial cells and of producing toxin was compared with that of three mutants derived from it that were altered in both or either of these cell properties. The results of studies on several models in animals (the ileal loop in rabbits and starved guinea pigs and monkeys) indicate that the disease caused by a nontoxigenic, penetrating mutant was not easily distinguishable from that of the original toxin-producing parent strain. A nonpenetrating mutant that had retained the ability to produce toxin and a double mutant that lacked ability to penetrate and produce toxin did not cause clinical disease. These findings do not exclude a function for toxin in the pathogenesis of dysentery by S. dysenteriae but indicate that the ability to penetrate and multiply in the colonic mucosa is more important in causing disease.