Anterior segment optical coherence tomography: assisted topographic corneal epithelial thickness distribution imaging of a keratoconus patient.
Anterior segment optical coherence tomography: assisted topographic corneal epithelial thickness distribution imaging of a keratoconus patient.
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DOI：
10.1159/000350630
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发表时间：
2013-01
影响因子：
0.4
通讯作者：
Asimellis G
中科院分区：
文献类型：
--
作者：
Kanellopoulos AJ;Asimellis G
评价基于眼前节光学相干断层扫描（AS-OCT）测量圆锥角膜患者上皮厚度的安全性、有效性和易用性。一名25岁男性患者，先前诊断为圆锥角膜，双眼表现高度不对称，接受了AS-OCT角膜上皮成像。我们研究了上皮厚度和上皮地形厚度分布。受影响较小的右眼（OD）的平均上皮厚度为51.97 ± 0.70，受影响较大的左眼（OS）的平均上皮厚度为55.65 ± 1.22。OD的局部上皮厚度变异性为1.53 ± 0.21 μm，而OS的局部上皮厚度变异性为9.80 ± 0.41 μm。这个病例进一步支持了我们以前的发现，即与正常眼相比，圆锥角膜眼的总上皮厚度增加的高频超声测量。AS-OCT进一步提供了易用性和可能更高的测量可预测性。该病例报告基于AS-OCT成像，证实了圆锥角膜眼的总体上皮厚度增加，如先前研究所介绍的[Kanellopoulos等人：Clin Ophthalmol 2012;6：789-800]，基于高频扫描超声生物显微镜成像。
To evaluate safety, efficacy and ease of measurement of epithelial thickness in a keratoconic patient based on anterior segment optical coherence tomography (AS-OCT). A 25-year-old male patient, previously diagnosed with keratoconus, with highly asymmetric manifestation among the two eyes, was subjected to AS-OCT corneal epithelial imaging. We investigated epithelial thickness and epithelial topographic thickness distribution. Mean epithelial thickness was 51.97 ± 0.70 for the less affected right eye (OD), and 55.65 ± 1.22 for the more affected left eye (OS). Topographic epithelial thickness variability for the OD was 1.53 ± 0.21 μm, while for the OS it was 9.80 ± 0.41 μm. This case further supports our previous findings with high-frequency ultrasound measurements of the increase in overall epithelial thickness in keratoconic eyes in comparison with normal eyes. AS-OCT further offers ease of use and possibly higher predictability of measurement. This case report, based on AS-OCT imaging, verifies increased overall epithelial thickness in keratoconic eyes, as introduced by a previous study [Kanellopoulos et al.: Clin Ophthalmol 2012;6:789–800], based on high-frequency scanning ultrasound biomicroscopy imaging.