RELATION BETWEEN BLOOD-PRESSURE AND RENIN, RENIN SUBSTRATE, ANGIOTENSIN-II, ALDOSTERONE AND URINARY SODIUM AND POTASSIUM IN 574 AMBULATORY SUBJECTS
RELATION BETWEEN BLOOD-PRESSURE AND RENIN, RENIN SUBSTRATE, ANGIOTENSIN-II, ALDOSTERONE AND URINARY SODIUM AND POTASSIUM IN 574 AMBULATORY SUBJECTS
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DOI：
10.1161/01.hyp.1.3.287
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发表时间：
1979-01-01
期刊：
影响因子：
8.3
通讯作者：
HERMANN, J
中科院分区：
文献类型：
--
作者：
WALKER, WG;WHELTON, PK;HERMANN, J
574例血压范围为94/58至250/145 mm Hg的动态受试者进行了日常饮食和钠摄入量的研究。比较血浆肾素、肾素底物、血管紧张素II、醛固酮、尿钠、尿钾与血压的关系，分析这些变量对血压变化的贡献。我们的分析显示，肾素底物与舒张压高度正相关（r = +0.39; p < 0.00001），但肾素-醛固酮系统的所有其他组分与血压呈显著负相关。钾，肾素-醛固酮系统和血压之间的高度显着的关系被发现，但没有这样的关系可以证明钠。血压较高的受试者尿钾浓度较低，钾/肌酸比率较低。这些发现提出了钾和高血压之间存在显著发病关系的可能性。多元线性回归显示，在这些受试者中，肾素-血管紧张素-醛固酮系统的影响只能解释血压所表现出的方差的不到20%。
Five hundred and seventy-four ambulatory subjects with blood pressures ranging from 94/58 to 250/145 mm Hg were studied on their usual dietary and sodium intake. Renin, renin substrate, angiotensin II, aldosterone and urinary sodium and potassium were compared with blood pressure to access the contribution of these variables to the blood pressure variance. Our analyses revealed that renin substrate was highly and positively correlated with diastolic blood pressure (r = +0.39; p < 0.00001) but all other components of the renin-aldosterone system exhibited a significant negative correlation with blood pressure. A highly significant relationship between potassium, the renin-aldosterone system and blood pressure was found but no such relationship could be demonstrated for sodium. Subjects with higher blood pressures had lower urinary potassium concentrations and lower potassium/creatine ratios. These findings raised the possibility of a significant pathogenetic relationship between potassium and high blood pressure. Multiple linear regression reveals that influences of the renin-angiotensin-aldosterone system can only account for less than 20% of the variance exhibited by the blood pressure in these subjects.