Impact of enriched-environment housing on brain-derived neurotrophic factor and on cognitive performance after a transient global ischemia
Impact of enriched-environment housing on brain-derived neurotrophic factor and on cognitive performance after a transient global ischemia
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DOI：
10.1016/j.bbr.2003.10.017
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发表时间：
2004-07-09
影响因子：
2.7
通讯作者：
O'Mara, SM
中科院分区：
文献类型：
--
作者：
Gobbo, OL;O'Mara, SM
丰富的环境促进大脑的结构和功能变化，包括增强啮齿动物的学习和记忆能力。短暂性全脑缺血（15分钟）导致大鼠背海马CA1区锥体细胞的特异性损伤，同时伴有认知缺陷。因此，我们研究了环境丰富是否可以保护大鼠免受短暂缺血的认知和神经后果。我们评估了三个任务的学习和记忆障碍：气味辨别，物体探索和空间学习。与预期相反，我们发现，丰富的环境改善性能的缺血和假大鼠在气味的歧视和对象的探索任务相比，标准条件圈养大鼠。暴露于丰富的环境后，缺血大鼠在水迷宫中的表现优于标准住房条件下的表现。然而，暴露于丰富的环境并不能防止CA1锥体细胞的实际损失。与标准条件下饲养的动物相比，环境富集动物的脑源性神经营养因子（BDNF）水平增加。我们的结论是，环境丰富有积极的影响，是独立的缺血性脑病变的影响。(C)2003 Elsevier B.V.保留所有权利。
Environmental enrichment promotes structural and functional changes in the brain, including enhanced learning and memory performance in rodents. Transient global cerebral ischemia (15 min) causes specific damage to dorsal hippocampal area CA1 pyramidal cells of the rat concomitantly with cognitive deficits. Thus, we investigated if environmental enrichment can protect rats against the cognitive and neurological consequences of transient ischemia. We evaluated the impairment of learning and memory with three tasks: odour discrimination, object exploration and spatial learning. Contrary to expectation, we found that the enriched environment improved performances for both ischemic and sham rats in odour discrimination and object exploration tasks compared with standard condition housed rats. After exposure to an enriched environment, ischemic rats performed better in the water maze than those in the standard housing conditions. However, exposure to an enriched environment does not protect against actual loss of CA1 pyramidal cells. Brain-derived neurotrophic factor (BDNF) levels were increased in environmental enrichment animals compared to those housed in standard conditions. We conclude that environmental enrichment has positive effects that are independent of the effects of ischemic brain lesions. (C) 2003 Elsevier B.V. All rights reserved.