Cellular responses to misfolded proteins and protein aggregates.
Cellular responses to misfolded proteins and protein aggregates.
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DOI：
10.1007/978-1-61779-474-2_32
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Cyr, Douglas M
中科院分区：
文献类型：
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作者：
Houck, Scott A;Singh, Sangita;Cyr, Douglas M
蛋白质组的维持是细胞的一项主要稳态任务，蛋白质稳态的失调可能是致命的。不同形式的错误折叠蛋白质的积累会扰乱蛋白质稳态并导致广泛的细胞和组织损伤。细胞具有各种质量控制系统来帮助防止错误折叠蛋白质的积累，并且已经进化的不同机制的复杂性令人眼花缭乱。所有质量控制系统的首要任务是识别错误折叠的蛋白质，然后做出分类决定。在许多情况下，模块化分子伴侣在不同的组装体中与降解或折叠辅助因子一起发挥作用，引导错误折叠的蛋白质继续生存或死亡。本文概述了对可溶性胞浆蛋白、蛋白聚集体和 ER 相关蛋白进行分类的质量控制机制。
Maintenance of the proteome is a major homeostatic task of the cell and disregulation of protein homeostasis can be deadly. The accumulation of different forms of misfolded protein can perturb protein homeostasis and cause extensive cell and tissue damage. The cell has various quality control systems to help prevent the accumulation of misfolded proteins and the complexity of the different mechanisms that have evolved is bewildering. The first order of business for all quality control systems is recognition of misfolded proteins, which is followed by a triage decision. In many cases, modular molecular chaperones function in different assemblies with degradatory or folding co-factors to direct a misfolded protein toward continued life or death. Herein, an overview of quality control mechanisms that triage soluble cytosolic proteins, protein aggregates, and ER-associated proteins is presented.