Enantioselective reduction of α,β-enones using an oxazaborolidine catalyst generated in situ from a chiral lactam alcohol
Enantioselective reduction of α,β-enones using an oxazaborolidine catalyst generated in situ from a chiral lactam alcohol
复制标题
DOI：
10.1016/j.tetasy.2011.10.018
复制
发表时间：
2011-11-30
影响因子：
--
通讯作者：
Yanagita, Ryo C.
中科院分区：
文献类型：
--
作者：
Kawanami, Yasuhiro;Mikami, Yudai;Yanagita, Ryo C.
研究发现，由手性内酰胺醇3和4-碘苯氧基硼烷原位制备的恶唑硼烷催化剂可在-40℃下催化α,β-烯酮的对映选择性还原，对映选择性高达90% ee。 (C) 2011 Elsevier Ltd. 保留所有权利。
The oxazaborolidine catalyst prepared in situ from the chiral lactam alcohol 3 and 4-iodophenoxyborane was found to catalyze the enantioselective reduction of alpha,beta-enones at -40 degrees C with a high level of enantiselectivity of up to 90% ee. (C) 2011 Elsevier Ltd. All rights reserved.