Adherence to highly active antiretroviral therapy and its correlates among HIV infected pediatric patients in Ethiopia
Adherence to highly active antiretroviral therapy and its correlates among HIV infected pediatric patients in Ethiopia
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DOI：
10.1186/1471-2431-8-53
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发表时间：
2008-12-06
期刊：
影响因子：
2.4
通讯作者：
Deribe, Kebede
中科院分区：
文献类型：
--
作者：
Biadgilign, Sibhatu;Deribew, Amare;Deribe, Kebede
背景：联合抗逆转录病毒疗法（ART）的引入导致了艾滋病毒相关死亡率的显著下降。尽管抗逆转录病毒疗法的供应增加，但儿童仍然是一个被忽视的群体。这可能是由于人们担心，未能坚持似乎与病毒的持续复制，治疗失败和耐药株的出现有关。本研究旨在确定2008年在埃塞俄比亚阿迪斯接受高效抗逆转录病毒治疗（HAART）的HIV感染儿童中抗逆转录病毒（ARV）药物治疗依从性的相关因素和比率。方法：2008年2月18日至4月28日在阿迪斯的5家医院进行横断面研究。研究人群包括在卫生机构接受抗逆转录病毒治疗的父母/看护人和索引儿童。结果：共调查390名儿童，总有效率为91%。大多数儿童，即205名儿童（52.6%），年龄在9岁以上。55%的儿童是女孩。共有339名儿童（86.9%）的报告，照顾者坚持抗逆转录病毒药物在过去7天前的采访。许多变量被发现与依从性显著相关：父母不支付治疗费用的儿童[OR = 0.39（95%CI：0.16，0.92）]，曾从诊所接受任何营养支持的儿童[OR = 0.34（95%CI：0.14，0.79）]不太可能依从。而在抗逆转录病毒药物的基础上服用复方新诺明药物/糖浆的儿童[OR = 3.65（95%CI：1.24，10.74）]，不知道自身血清学状态的儿童[OR = 2.53（95%CI：1.24，5.19）]和不知道照顾者健康问题的儿童[OR = 2.45（95%CI：1.25，4.81）]更可能坚持比他们的people.Conclusion：坚持HAART儿童在阿迪斯高于其他类似的设置。然而，仍有相当数量的儿童不遵守高效抗逆转录病毒疗法。
Background: The introduction of combination antiretroviral therapy (ART) has resulted in striking reductions in HIV-related mortality. Despite increased availability of ART, children remain a neglected population. This may be due to concerns that failure to adhere appears to be related to continued viral replication, treatment failure and the emergence of drug-resistant strains of HIV. This study determines the rates and factors associated with adherence to Antiretroviral (ARV) Drug therapy in HIV-infected children who were receiving Highly Active Antiretroviral Therapy (HAART) in Addis Ababa, Ethiopia in 2008.Methods: A cross-sectional study was conducted in five hospitals in Addis Ababa from February 18-April 28, 2008. The study population entailed parents/caretaker and index children who were following ART in the health facilities. A structured questionnaire was used for data collection.Results: A total of 390 children respondents were included in the study with a response rate of 91%. The majority, equaling 205 (52.6%) of the children, were greater than 9 years of age. Fifty five percent of the children were girls. A total of 339 children (86.9%) as reported by caregivers were adherent to antiretroviral drugs for the past 7 days before the interview. Numerous variables were found to be significantly associated with adherence: children whose parents did not pay a fee for treatment [OR = 0.39 (95% CI: 0.16, 0.92)], children who had ever received any nutritional support from the clinic [OR = 0.34 ( 95% CI: 0.14, 0.79)] were less likely to adhere. Whereas children who took co-trimoxazole medication/syrup besides ARVs [OR = 3.65 ( 95% CI: 1.24, 10.74)], children who did not know their sero-status [OR = 2.53 ( 95% CI: 1.24, 5.19)] and children who were not aware of their caregiver's health problem [OR = 2.45 ( 95% CI: 1.25, 4.81)] were more likely to adhere than their counterparts.Conclusion: Adherence to HAART in children in Addis Ababa was higher than other similar setups. However, there are still significant numbers of children who are non-adherent to HAART.