Cancer mortality among Japanese immigrants and their descendants in the state of Sao Paulo, Brazil, 1999-2001
Cancer mortality among Japanese immigrants and their descendants in the state of Sao Paulo, Brazil, 1999-2001
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DOI：
10.1093/jjco/hyh123
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发表时间：
2004-11-01
影响因子：
2.4
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Iwasaki, Motoki;Mameri, Cecilia Polidoro;Tsugane, Shoichiro
背景：尽管巴西的日本移民人口众多，而且他们的环境和生活方式与生活在日本的日本人不同，但对日本移民死亡率的研究却很少。方法：为了比较在日本的日本人与在巴西圣保罗州的日本移民或巴西人的癌症死亡率，我们获得了1999-2001年登记的官方死亡证明。以日本人在日本的死亡率数据为标准，计算了第一代日本移民（日本出生）、他们在巴西出生的日本后裔和巴西本土巴西人主要癌症部位的标准化死亡率（SMR）或标准化比例死亡率（SPMR）。结果：日本出生的巴西居民与日本本地人的胃癌和结直肠癌的smr无显著差异，但巴西本地人的smr明显较低。与日本本地人相比，我们观察到日本出生的巴西人和巴西人的肝癌、胆囊癌和肺癌的smr显著降低，前列腺癌、宫颈癌、脑癌和神经系统癌的smr显著升高。一般来说，SPMR的结果与SMRs的结果相似。在巴西出生的日本人和在巴西出生的人患乳腺癌和子宫癌的spmr都很高，尽管日本出生的人的smmr增加了，但并不明显。结论：我们证实了日本移民与日本本土的癌症死亡率模式不同，从而证明了环境在癌症发展中的相对重要性。
Background: Only a few studies on the mortality of Japanese immigrants have been conducted in Brazil despite a large population of Japanese immigrants and their different environment and lifestyle from Japanese living in Japan.Methods: To compare cancer mortality between Japanese in Japan and Japanese immigrants or Brazilians in the state of Sao Paulo, Brazil, we obtained official death certificates registered during 1999-2001. The standardized mortality ratio (SMR) or the standardized proportional mortality ratio (SPMR) of major cancer sites was calculated for the first generation of Japanese immigrants to Brazil (Japan-born), their Brazil-born Japanese descendants, and native Brazilians using mortality data of Japanese in Japan as a standard.Results: The SMRs of stomach and colorectal cancer did not differ between the Japan-born residents of Brazil and the native Japanese, but significantly low SMRs were found among the native Brazilians. Compared with the native Japanese, we observed significantly lower SMRs for liver, gallbladder and lung cancer and significantly higher SMRs for prostate, cervical, and brain and nervous system cancer among both the Japan-born residents of Brazil and the Brazilians. Generally, the SPMR results were similar to those of the SMRs. Significantly high SPMRs for breast and uterine cancer were found for both the Japan- and Brazil-born residents of Brazil, although the Japan-born residents had increased SMRs, but not significantly so.Conclusions: We confirmed the different cancer mortality pattern in the Japanese immigrants from that in Japanese in Japan, thus demonstrating the relative importance of the environment in the development of cancer.