Tissue engineering scaffold material of nano-apatite crystals and polyamide composite
Tissue engineering scaffold material of nano-apatite crystals and polyamide composite
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DOI：
10.1016/j.eurpolymj.2003.10.028
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发表时间：
2004-03-01
影响因子：
6
通讯作者：
Li, Y
中科院分区：
文献类型：
--
作者：
Jie, W;Li, Y
采用共溶液法、共沉淀法和常压水处理法制备了针状纳米羟基磷灰石（n-HA）和聚酰胺（PA）生物复合材料新型组织工程支架材料。纳米羟基磷灰石（n-HA）晶体在复合材料中均匀分布，晶体直径为10-20 nm，长度为70-90 nm。该复合材料具有良好的均匀性、较高的n-HA含量（65wt%）和较高的生物活性。IR、XPS和XRD分析表明，复合材料中n-HA与PA之间存在较强的分子间相互作用和化学键合。该复合材料具有接近天然骨的优异力学性能。采用注射发泡法制备多孔三维支架，支架上既有大孔，又有微孔。该复合材料的孔隙率为80%，平均大孔径约为300 μ m。n-HA/PA复合材料可用于组织工程和骨修复或替代。(C)2003爱思唯尔有限公司。保留所有权利。
A new kind of tissue engineering scaffold materials of needle-like nano-hydroxyapatite (n-HA) and polyamide (PA) biocomposite is prepared by co-solution, co-precipitation method and water treatment under normal atmospheric pressure. The n-HA crystals uniformly distribute in the composite with a crystal size of 10-20 nm in diameter by 70-90 nm in length. The n-HA/PA composite has good homogeneity, high n-HA content (65 wt%), and high bioactivity. Strong molecule interactions and chemical bondings are present between the n-HA and PA in the composite, which are verified by IR, XPS and XRD. The composite has excellent mechanical properties close to the natural bone. The porous 3-D scaffold is made by injection foaming method, which has not only macropores, but also micropores on the walls of macropores. The porosity is 80% and the average macropore diameter is about 300 mum of the composite. The n-HA/PA composite can be used for tissue engineering and bone repair or substitute. (C) 2003 Elsevier Ltd. All rights reserved.