Antitumor and antimetastatic activities of Rhizoma Paridis saponins
Antitumor and antimetastatic activities of Rhizoma Paridis saponins
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DOI：
10.1016/j.steroids.2009.08.004
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发表时间：
2009-11-01
期刊：
影响因子：
2.7
通讯作者：
Huang, Luqi
中科院分区：
文献类型：
--
作者：
Man, Shuli;Gao, Wenyuan;Huang, Luqi
重楼皂苷（RPS）具有较强的抗肿瘤活性。然而，很少有研究探讨其对肺转移的作用。为了研究转移的相关分子机制，我们采用组织病理学方法对rps处理的T739小鼠进行了研究。免疫组织化学和逆转录聚合酶链反应。TUNEL法检测细胞凋亡。结果表明，RPS通过诱导细胞凋亡抑制肿瘤生长，上调TIMP-2的表达，并调节MMP-2和MMP-9的水平。综上所述，RPS是一种有效的抗癌药物，可在体内诱导细胞程序性死亡并抑制肺腺癌的转移。(C) 2009爱思唯尔公司版权所有。
Rhizoma Paridis saponins (RPS) have been found to show strong antitumor activity. However, few studies have yet investigated its role on pulmonary metastasis treated with this herb. To investigate the molecular mechanisms related to metastasis, we studied RPS-treated T739 mice using histopathology. immunohistochemistry and reverse transcription polymerase chain reaction. Apoptosis was measured by TUNEL assay. As a result, RPS inhibited tumor growth by inducing apoptosis and upregulated the expression of TIMP-2 and clown-regulated the level of MMP-2 and MMP-9. In conclusion, RPS is a potent anticancer agent that elicits programmed cell death and inhibits metastases in murine lung adenocarcinoma in vivo. (C) 2009 Elsevier Inc. All rights reserved.