EFFECT OF ROUTE OF INFECTION ON THE FREQUENCY AND DISTRIBUTION OF CEREBRAL AMYLOID PLAQUES IN SCRAPIE MICE
EFFECT OF ROUTE OF INFECTION ON THE FREQUENCY AND DISTRIBUTION OF CEREBRAL AMYLOID PLAQUES IN SCRAPIE MICE
复制标题
感染途径对瘙痒症小鼠脑淀粉样斑块发生频率和分布的影响
DOI：
--
复制
发表时间：
1981
影响因子：
5
通讯作者：
H. Fraser
中科院分区：
文献类型：
--
作者：
M. Bruce;H. Fraser
脑淀粉样斑块是感染某些羊瘙痒病菌株的小鼠的显著病理特征。这些斑块中淀粉样蛋白的来源，无论是局部还是全身合成，以及导致其沉积的机制尚不清楚。斑块的频率及其在脑中的分布受羊瘙痒病接种物的注射途径的影响很大。脑内注射始终导致更大数量的斑块比，如果相同的接种物被引入外周。脑内注射后，斑块通常出现在靠近侧脑室的区域，例如胼胝体和海马，而这些区域不存在外周途径。此外，当比较左侧和右侧脑内注射时，注射侧的斑块更常见。这些结果表明，淀粉样蛋白斑块的分布受到接种物的某些成分的定位或注射时的创伤性损伤的影响。最合理的解释是淀粉样蛋白沉积与瘙痒病感染性的局部集中有关，并且淀粉样蛋白起源于大脑。
Cerebral amyloid plaques are a conspicuous pathological feature in mice infected with certain strains of scrapie. The origin of the amyloid protein in these plaques, whether it is locally or systemically synthesized, and the mechanisms leading to its deposition are not known. The frequency of plaques and their distribution in the brain are greatly influenced by the route of injection of the scrapie inoculum. Intracerebral injection consistently results in greater numbers of plaques than are obtained if the same inoculum is introduced peripherally. Following intracerebral injection, plaques are commonly seen in areas close to the lateral ventricles, for example the corpus callosum and hippocampus, whereas they are absent from these areas with peripheral routes. Furthermore, when left‐ and right‐ sided intracerebral injections are compared, plaques are more frequent on the side of injection. These results suggest that the distribution of amyloid plaques is influenced either by the localization of some component of the inoculum or by traumatic damage at injection. The most plausible explanation is that amyloid deposition is associated with local concentrations of scrapie infectivity and that the amyloid protein originates in the brain.