Protein Adsorption on Biomaterials
Protein Adsorption on Biomaterials
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生物材料上的蛋白质吸附
DOI：
10.1021/ba-1982-0199.ch017
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
T. Horbett
中科院分区：
文献类型：
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作者：
T. Horbett
寻找用于与组织接触的可接受材料的问题与当今的临床实践高度相关。该问题的困难反映了组织-材料相互作用的复杂性质，其受到组织性质、材料性质以及植入物周围流体输送的影响。考虑到这些方面的植入物设计可能会产生一个“生物相容性环境”，类似于血液相容性所需的非血栓形成环境（1）。软组织植入物周围发生的异物反应和与血液接触表面上的血栓形成是植入物遇到的主要反应。这两种反应都涉及细胞与植入物的相互作用，特别是在后期阶段，因此以前的许多研究都强调了生物相容性过程中的细胞事件。然而，在确保预先吸附一层蛋白质的条件下，细胞遇到外来聚合物植入物
The problem of finding acceptable materials for use in contact with tissue is highly relevant to present day clinical practice. The difficulty of this problem reflects the complex nature of tissue-material interactions which are influenced by properties of the tissue, properties of the material, and by the transport of fluids around the implant. Implants designed with each of these aspects in mind may produce a "biocompatible environment," analogous to the nonthrombogenic environment thought to be required for blood compatibility (1).The foreign body reaction occurring around soft tissue implants and thrombosis on surfaces in contact with blood are the major reactions encountered with implants. Both reactions involve the interaction of cells with the implant, especially in the later stages, and much previous study has therefore emphasized cellular events in the biocompatibility process. However, cells encounter foreign polymer implants under conditions that ensure the prior adsorption of a layer of protein