LP-BM5 infection impairs acquisition, but not performance, of active avoidance responding in C57B1/6 mice.
LP-BM5 infection impairs acquisition, but not performance, of active avoidance responding in C57B1/6 mice.
复制标题
LP-BM5 感染会损害 C57B1/6 小鼠主动回避反应的获得，但不会损害其表现。
DOI：
10.1096/fasebj.12.2.175
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Paul,IA
中科院分区：
文献类型：
--
作者：
English,JA;Hemphill,KM;Paul,IA
LP‐BM5 murine leukemia virus infection causes an AIDS‐like syndrome—murine acquired immunodeficiency syndrome— in C57Bl/6 mice and impairs spatial learning in the Morris water maze without gross motor impairment. We used a shuttle shock‐avoidance procedure to examine the effects of LP‐BM5 infection on learning and retention of avoidance behavior. Thirty mice were inoculated with LP‐BM5; 30 received vehicle (DMEM) injections. Fifteen LP‐BM5 and 15 DMEM mice were trained in avoidance 7 wk after inoculation; retention of the avoidance response was tested 4 wk later. The remaining mice were trained 11 wk after inoculation. In animals trained 7 wk after inoculation, the groups performed similarly, with a marginally significant tendency for LP‐BM5‐infected animals to make more avoidance responses. This group difference was significant when animals were retested at 11 wk. However, LP‐BM5 animals trained 11 wk after inoculation made significantly fewer avoidance responses than controls trained at the same time. We conclude that in later stages of disease, LP‐BM5 impairs response acquisition, but not performance, in the active avoidance procedure. Results extend the use of the LP‐BM5‐infected mouse as a model of AIDS dementia complex.—English, J. A., Hemphill, K. M., Paul, I. A. LP‐BM5 infection impairs acquisition, but not performance, of active avoidance responding in C57Bl/6 mice.FASEB J.12, 175–179 (1998)
