Quantitative autoradiographic mapping of a novel serotonin receptor-5-HT1S
Quantitative autoradiographic mapping of a novel serotonin receptor-5-HT1S
复制标题
DOI：
10.1097/00001756-199210000-00004
复制
发表时间：
1992-10
期刊：
影响因子：
1.7
通讯作者：
Murphy Rm;Zemlan Fp
中科院分区：
文献类型：
--
作者：
Murphy Rm;Zemlan Fp
采用定量放射自显影显微密度法研究了最近发现的高亲和力3H-5-HT结合位点5-HT1S受体的脊髓分布。测定了大鼠脊髓中其他高亲和力3H-5-HT结合位点5-HT1A、5-HT1B和5-HT1C的层流分布和密度。5-HT1S受体密度最大的部位为背角浅层、中央管周围的自主神经核和腹侧运动核。在脊髓其他区域观察到较小的、可变密度的5-HT1S受体。5-HT1A、5-HT1B和5-HT1C受体密度的空间分布规律相似。5-HT1S受体的分布提示了脊髓体感觉输入的功能调节以及内脏和躯体运动活动的控制。
The spinal cord distribution of a recently identified, high affinity 3H-5-HT binding site, the 5-HT1S receptor was studied employing quantitative autoradiography with microdensitometry. The laminar distribution and density of other high affinity 3H-5-HT binding sites present in rat spinal cord, 5-HT1A, 5-HT1B and 5-HT1C, was also determined. The greatest density of 5-HT1S receptors was found in the superficial dorsal horn laminae, the autonomic nuclei around the central canal and the ventral motor nuclei. Smaller, variable densities of 5-HT1S receptors were observed in other spinal cord regions. A similar spatial pattern of receptor density was observed for 5-HT1A, 5-HT1B and 5-HT1C receptors. The distribution of 5-HT1S receptors suggests functional modulation of somatosensory input to spinal cord as well as control of visceral and somatomotor activity.