Central vein sign detected by SWI at 3 T MRI as a discriminator between multiple sclerosis and leukoaraiosis
Central vein sign detected by SWI at 3 T MRI as a discriminator between multiple sclerosis and leukoaraiosis
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DOI：
10.1016/j.ejrnm.2017.09.003
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发表时间：
2018-03-01
影响因子：
1
通讯作者：
Al-Waely, Noor K. N.
中科院分区：
文献类型：
--
作者：
Al-Zandi, Shirin H.;Fayadh, Noor A. H.;Al-Waely, Noor K. N.
背景：MRI是诊断多发性硬化症的重要工具，但与非特异性脑白质病变仍有重叠。MR敏感性加权成像检测中心静脉征可提高MRI对MS的诊断准确率。目的：评价中心静脉征在MS和脑白质疏松-WML鉴别诊断中的价值。在轴位FLAIR上，计数脑白质病变&Gt；=5 mm，然后在轴位SWI序列上评估中央静脉的存在。结果：86.84%的MS病变检出CVS，13.33%的脑白质疏松病变检出CVS，两者差异有统计学意义，单个CVS阳性病变诊断MS的敏感性、特异性、阳性预测值和阴性预测值分别为86.84%、86.6%、88.7%和75.72%。当CVS阳性病变负荷为-gt；=47.5%时，特异性为100%。结论：中心静脉征是鉴别MS和脑白质疏松的可靠指标。
Background: MRI is an essential tool for diagnosing multiple sclerosis; however, overlap with nonspecific white matter lesions still exists. The central vein sign as detected by MR susceptibility weighted imaging has been proposed to improve the diagnostic accuracy of MRI in MS.Purpose: To assess the value of the central vein sign at susceptibility weighted imaging in discriminating between MS WMLs and leukoaraiosis-WMLs.Patients and methods: Thirty MS patients and 30 patients with leukoaraiosis, matched for age and gender were included in this study. On axial FLAIR, white matter lesions >= 5 mm were counted and subsequently assessed on the axial SWI sequence for the presence of the central vein. The cut-off value of CVS positivity of lesions was evaluated using ROC curve.Results: CVS was detected in 86.84% of MS lesions and in 13.33% of leukoaraiosis lesions with statistically significant difference.The sensitivity, specificity, positive and negative predictive values of individual CVS positive lesion in diagnosing MS were 86.84%, 86.6%, 88.7% and 75.72% respectively. A specificity of 100% was attained when CVS positive lesion load is >= 47.5%.Conclusion: Central vein sign is a fairly reliable discriminator between MS and leukoaraiosis.