Infiltration by immunocompetent cells in early stage invasive carcinoma of the uterine cervix: A prognostic study
Infiltration by immunocompetent cells in early stage invasive carcinoma of the uterine cervix: A prognostic study
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DOI：
10.1080/00313029600169274
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发表时间：
1996-11-01
期刊：
影响因子：
4.5
通讯作者：
Delahunt, B
中科院分区：
文献类型：
--
作者：
Bethwaite, PB;Holloway, LJ;Delahunt, B
在各种肿瘤类型中，树突状细胞浸润和肿瘤浸润淋巴细胞的存在与改善的临床结果相关。在子宫颈中，这些免疫活性细胞与改善高阶段疾病的预后有关。目前的研究探讨了一系列的73名妇女的低阶段（FIGO Ib）浸润性鳞状和腺鳞癌宫颈癌的间质和肿瘤T淋巴细胞浸润的意义，以及S-100阳性树突状细胞浸润。34%的病例含有S-100阳性树突状细胞。这些在盆腔复发或远处疾病的病例中代表性不足（1/11与24/62无复发，P = 0.05），在淋巴/毛细血管间隙受累的病例中代表性过高（12/23与13/46无血管间隙浸润，P = 0.05）。这些妇女平均随访5.2年，肿瘤中含有S-100阳性树突状细胞的妇女的5年生存率为92%，而阴性病例为73%（P = 0.04）。低密度肿瘤浸润性T细胞与盆腔淋巴结扩散和随后的局部或远处疾病控制失败的风险之间存在显著相关性（P = 0.008）。与较低计数（68%）相比，每个高倍视野5个或更多CD 3阳性肿瘤浸润T淋巴细胞（90%）的5年生存率更高（P = 0.04）。对于T细胞的高基质浸润，不能证明类似的优势。到目前为止，诱导这些细胞浸润某些宫颈癌的具体机制和这些细胞在肿瘤组织中协调的免疫损伤的性质都还不清楚。
In various tumor types dentritic cell, infiltration and the presence of tumor-infiltrating lymphocytes have been associated with an improved clinical outcome. In the uterine cervix these immunocompetent cells have been associated with improved prognosis in high stage disease. The current study examines the significance of stromal and tumor T-lymphocyte infiltration together with S-100 positive dendritic cell infiltration in a series of 73 women with low stage (FIGO Ib) invasive squamous and adenosquamous cervical carcinoma. Thirty four percent of cases contained S-100 positive dendritic cells. These were under-represented in cases showing pelvic recurrence or distant disease (1 of 11 compared to 24 of 62 free of recurrence, P = 0.05) and over-represented in cases showing lymphatic/capillary space involvement (12 of 23 compared to 13 of 46 without vascular space invasion, P = 0.05). The women were followed up for an average of 5.2 years and the five-year survival for women whose tumors contained S-100 positive dendritic cells was 92% compared to 73% for negative cases (P = 0.04). There was a significant association between a low density of tumor infiltrating T-cells and risk of pelvic lymph node spread and subsequent local or distant disease control failure (P = 0.008). A five year survival advantage was seen with five or more CD 3 positive tumor infiltrating T-lymphocytes per high power field (90%) compared to a lower count (68%) (P = 0.04). A similar advantage could not be demonstrated for a high stromal infiltrate of T-cells. As yet neither the specific mechanisms that induce these cells to infiltrate some cervical carcinomas nor the nature of the immunologicaI injury that the cells co-ordinate in tumor tissue are well understood.