Relationship between insulin resistance and inflammatory markers and anti-inflammatory effect of losartan in patients with type 2 diabetes and hypertension
Relationship between insulin resistance and inflammatory markers and anti-inflammatory effect of losartan in patients with type 2 diabetes and hypertension
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DOI：
10.1016/j.cca.2006.06.004
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发表时间：
2006-12-01
影响因子：
5
通讯作者：
Nakamura, Naoto
中科院分区：
文献类型：
--
作者：
Park, Hyohun;Hasegawa, Goji;Nakamura, Naoto
背景资料：它是现在公认的血管炎症和内皮功能障碍与心血管疾病有助于insulinresistance.Methods：我们调查之间的关系的稳态模型评估胰岛素抵抗指数（HOMA-R）和各种血清炎症标志物和氯沙坦对这些标志物的血清浓度在2型糖尿病和高血压患者。根据HOMA-R值将患者分为2组，A组60例患者的HOMA-R值=2.4，B组44例患者的HOMA-R值> 2.5。结果：HOMA-R与TNF-α呈正相关（r=0.336，P < 0.01），与脂联素（r=-0.405，P <0.01）、细胞外超氧化物歧化酶（EC-SOD）呈负相关（r =-0.452，P < 0.01）。多元逐步回归分析显示HOMA-R之间存在显著相关性。脂联素（F=8.74）和EC-SOD（F=14.39）。结论：B型糖尿病合并高血压患者血清EC-SOD水平可能是反映胰岛素抵抗的敏感生化指标，氯沙坦可能通过增加EC-SOD和脂联素水平，降低TNF-α水平，改善胰岛素敏感性。(c)2006 Elsevier B. V.保留所有权利。
Background: It is now well established that vascular inflammation and endothelial dysfunction associated with cardiovascular diseases contributes to insulin resistance.Methods: We investigated the relationship between the homeostasis model assessment-insulin resistance index (HOMA-R) and various serum inflammatory markers and the effect of losartan on serum concentrations of these markers in patients with type 2 diabetes and hypertension. The patients were divided into 2 groups according to the value of HOMA-R with 60 patients with values=2.4 in Group A and 44 patients with values > 2.5 in Group B. The variables were measured at baseline and after 6 months of treatment with losartan (50 mg/day).Results: The HOMA-R concentrations were positively related to TNF-alpha (r=0.336, P < 0.01) and inversely related to adiponectin (r=-0.405, P < 0.01) and extracellular-superoxide dismutase (EC-SOD) (r=-0.452, P < 0.01). Stepwise multiple regression analysis showed a significant relationship between HOMA-R. and adiponectin (F=8.74) and EC-SOD (F=14.39). In Group B, losartan treatment significantly increased the serum concentrations of EC-SOD and adiponectin and decreased TNF-a and HOMA-R.Conclusion: Serum EC-SOD concentrations may be a sensitive biochemical marker of insulin resistance in patients with type 2 diabetes and hypertension and that losartan improves insulin sensitivity by increasing EC-SOD and adiponectin production and decreasing TNF-alpha production. (c) 2006 Elsevier B.V. All rights reserved.