EFFECT OF CORTICOTROPIN RELEASING HORMONE AND NEUROPEPTIDE-Y ON ELECTROPHYSIOLOGICAL ACTIVITY OF SYMPATHETIC-NERVES TO INTERSCAPULAR BROWN ADIPOSE-TISSUE
EFFECT OF CORTICOTROPIN RELEASING HORMONE AND NEUROPEPTIDE-Y ON ELECTROPHYSIOLOGICAL ACTIVITY OF SYMPATHETIC-NERVES TO INTERSCAPULAR BROWN ADIPOSE-TISSUE
复制标题
DOI：
10.1016/0306-4522(90)90181-3
复制
发表时间：
1990-01-01
期刊：
影响因子：
3.3
通讯作者：
BRAY, GA
中科院分区：
文献类型：
--
作者：
EGAWA, M;YOSHIMATSU, H;BRAY, GA
有人提出，食物摄入量和交感神经活动之间存在着相互作用的关系。为了验证这一假说，将抑制摄食行为的促肾上腺皮质激素释放激素和刺激摄食行为的神经肽Y分别注入大鼠的脑室，并将交感神经活动注入麻醉大鼠的肩峰间棕色脂肪组织。电生理记录交感神经向肩峰间棕色脂肪组织的多单位放电。侧脑室注射促肾上腺皮质激素释放激素(250和500pmol)增加交感神经活动，脑室注射神经肽Y(250-500pmoL)抑制交感神经活动，呈剂量依赖关系。侧脑室注射赋形剂不影响交感神经活动。这一结果与这些脑肽是交感神经系统的神经调节剂的假设是一致的，交感神经系统可能控制肩关节间棕色脂肪组织的支出。这两种脑肽对交感神经活动的影响与对摄食行为的影响相反，提示交感神经活动与摄食量可能是相互关联的。
It has been proposed that there is a reciprocal relationship between food intake and sympathetic activity. To test this hypothesis corticotropin releasing hormone, which suppresses feeding behavior, and neuropeptide Y, which stimulates it, were injected intracerebroventricularly and sympathetic nerve activity to interscapular brown adipose tissue measured in anesthetized rats. Multi-unit discharges of sympathetic nerves to interscapular brown adipose tissue were recorded electrophysiologically. The intracerebroventricular injection of corticotropin releasing hormone (250 and 500 pmol) increased sympathetic nerve activity and the intracerebroventricular injection of neuropeptide Y (250-500 pmol) suppressed sympathetic nerve activity in a dose-dependent manner. The intracerebroventricular injection of vehicle did not affect sympathetic nerve activity. The result is consistent with the hypothesis that these brain peptides are neuromodulators of the sympathetic nervous system which may control expenditure in the interscapular brown adipose tissue. The effects of these two brain peptide on sympathetic nerve activity are opposite to their effects on feeding behavior suggesting that sympathetic activity and food intake may be reciprocally related.