The quantitative monitoring of mechanochemical reaction between solid l-tartaric acid and sodium carbonate monohydrate by terahertz spectroscopy
The quantitative monitoring of mechanochemical reaction between solid l-tartaric acid and sodium carbonate monohydrate by terahertz spectroscopy
复制标题
太赫兹光谱定量监测固体l-酒石酸与一水碳酸钠的机械化学反应
DOI：
10.1016/j.jpcs.2011.07.011
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发表时间：
2011
影响因子：
4
通讯作者：
Xingtai Zhou
中科院分区：
文献类型：
--
作者：
Xiaohong Liu;Guifeng Liu;Hongwei Zhao;Zeng;Yong;Min Liu;W. Wen;Xingtai Zhou
利用太赫兹时域光谱技术研究了手性酒石酸与碱金属碳酸盐的固相反应。酒石酸钠二水合物是通过固态机械研磨高效合成的，没有浪费，特别是可持续和环境友好。观察到反应物和产物的不同太赫兹吸收。这表明太赫兹光谱对不同的材料和晶体结构敏感。选择酒石酸在1.09THz处的特征THz吸收峰进行定量分析。反应动力学符合二级动力学方程和Jander方程，符合三维扩散机理。采用同步辐射X射线粉末衍射（SRXRPD）、傅里叶变换红外光谱（FT-IR）和扫描电镜（SEM）等多种技术相结合的方法对粉磨过程进行了研究。结果表明，太赫兹光谱技术在医药和化学合成工业的过程监测和分析中具有巨大的应用潜力。
The solid-state reaction of chiral tartaric acid and alkali carbonate was studied by terahertz time-domain spectroscopy (THz-TDS). The sodium tartrate dihydrate was synthesized with high efficiency by mechanical grinding in the solid-state without waste that is particularly sustainable and environmentally benign. Distinct THz absorptions were observed for reactants and products. It indicates that THz spectroscopy is sensitive to different materials and crystal structures. The characteristic THz absorption peak at 1.09THz of l (+)-Tartaric acid was selected for quantitative analysis. The reaction kinetics could be expressed by the Second-order equation and the Jander equation, which is consistent with a three-dimensional diffusion mechanism. The combination of multi-techniques including synchrotron radiation X-ray powder diffraction (SRXRPD), Fourier transform infrared (FT-IR) and scanning electron microscopy (SEM) was used to investigate the grinding process and presented supporting evidences. The results demonstrate that THz spectroscopy technique has great potential applications in process monitoring and analysis in pharmaceutical and chemical synthesis industry.