Irisin: A promising treatment for neurodegenerative diseases
Irisin: A promising treatment for neurodegenerative diseases
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DOI：
10.1016/j.neuroscience.2022.07.018
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Shui-bing Liu
中科院分区：
文献类型：
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作者：
Jing-yu Qi;Liu-kun Yang;Xin-shang Wang;Min Wang;Xu-bo Li;Ban Feng;Yu-mei Wu;Kun Zhang;Shui-bing Liu
• Irisin mediates the beneficial effects of exercise on the CNS. • Irisin could improve the pathological feature of AD, PD and ALS. • Irisin has potential benefits to stroke, mental disorders, epilepsy and pain. • Irisin could become a potential therapeutic strategy for neurodegenerative diseases. The beneficial effects of exercise on human brain function have been demonstrated in previous studies. Myokines secreted by muscle have attracted increasing attention because of their bridging role between exercise and brain health. Regulated by PPARγ coactivator 1α, fibronectin type III domain-containing protein 5 releases irisin after proteolytic cleavage. Irisin, a type of myokine, is secreted during exercise, which induces white adipose tissue browning and relates to energy metabolism. Recently, irisin has been shown to exert a protective effect on the central nervous system. Irisin secretion triggers an increase in brain-derived neurotrophic factor levels in the hippocampus, contributing to the amelioration of cognition impairments. Irisin also plays an important role in the survival, differentiation, growth, and development of neurons. This review summarizes the role of irisin in neurodegenerative diseases and other neurological disorders. As a novel positive mediator of exercise in the brain, irisin may effectively prevent or decelerate the progress of neurodegenerative diseases in models and also improve cognitive functions. We place emphasis herein on the potential of irisin for prevention rather than treatment in neurodegenerative diseases. In ischemic diseases, irisin can alleviate the pathophysiological processes associated with stroke. Meanwhile, irisin has anxiolytic and antidepressant effects. The potential therapeutic effects of irisin in epilepsy and pain have been initially revealed. Due to the pleiotropic and beneficial properties of irisin, the possibility of irisin treating other neurological diseases could be gradually explored in the future.
