Mucous systems show a novel mechanical response to applied deformation
Mucous systems show a novel mechanical response to applied deformation
复制标题
DOI：
10.1021/bm049225i
复制
发表时间：
2005-05-01
影响因子：
6.2
通讯作者：
Smidsrod, O
中科院分区：
文献类型：
--
作者：
Taylor, C;Draget, KI;Smidsrod, O
粘液分泌物具有广泛的生物学功能，这些功能与其流变学特性密切相关。此外，许多粘液分泌物在生理功能期间暴露于显著的应力和变形。本研究已经检查了三个粘液系统，本地猪胃粘液，纯化的粘蛋白凝胶，和粘蛋白藻酸盐凝胶的流变学响应，以增加施加的应力到足以诱导流动行为的水平。一个新的，频率依赖性的应力硬化观察到在所有三个系统。这种硬化行为可能在粘液系统在生理状态下抵抗机械破坏的能力中起重要作用。
Mucous secretions have a wide range of biological functions that are intimately linked with their rheological properties. In addition, many mucous secretions are exposed to significant stress and deformation during physiological function. This study has examined the rheological response of three mucous systems, native pig gastric mucus, purified mucin gels, and mucin alginate gels, to increasing applied stress to a level sufficient to induce flow behavior. A novel, frequency-dependent stress hardening was observed in all three systems. This hardening behavior may play a significant role in the ability of mucous systems to resist mechanical disruption in the physiological state.