Effects of a single moderate dose of alcohol on blood pressure, heart rate and associated metabolic and endocrine changes.
Effects of a single moderate dose of alcohol on blood pressure, heart rate and associated metabolic and endocrine changes.
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单次中等剂量的酒精对血压、心率以及相关代谢和内分泌变化的影响。
DOI：
10.1042/cs0730411
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发表时间：
1987
期刊：
影响因子：
6
通讯作者：
G. Mcinnes
中科院分区：
文献类型：
--
作者：
D. Stott;S. Ball;G. Inglis;D. L. Davies;R. Fraser;G. Murray;G. Mcinnes
1.研究了10名健康受试者单次中剂量酒精对血压、心率及相关代谢和内分泌变化的影响，并与等热量葡萄糖控制饮料进行了比较。2.饮酒和对照饮品后1h，血压均升高。因此，这种早期的变化并不是特定的酒精摄入所致。随后，在饮酒后8小时内，有仰卧和直立的收缩压下降的趋势(没有统计学意义)。在饮酒后7天内，没有观察到持续的晚期血压变化。3.酒精引起仰卧和直立两种姿势的明显心动过速，持续时间超过可检测到的血液酒精水平。4.饮用酒精和等热量葡萄糖控制饮料后，血糖升高幅度相似，但峰值血浆胰岛素水平在对照饮料后升高。5.血钠升高与酒精性水尿相一致。饮酒后血浆钾、镁无明显变化。6.与对照饮料相比，循环肾上腺素、去甲肾上腺素、皮质醇、醛固酮或肾素的测定没有证据表明酒精引起交感肾上腺轴、肾上腺皮质或肾素-血管紧张素系统的激活。
1. The effects of a single moderate dose of alcohol on blood pressure, heart rate and associated metabolic and endocrine changes were studied in 10 healthy subjects and compared with those of an isocaloric glucose control drink. 2. Systolic blood pressure rose at 1 h after both alcohol and the control drink. Therefore this early change was not specifically due to alcohol ingestion. Subsequently, there was a tendency (not statistically significant) for supine and erect systolic blood pressure to be reduced up to 8 h after alcohol ingestion. There were no consistent late changes in blood pressure observed over 7 days after alcohol. 3. Alcohol caused a marked tachycardia in both supine and erect postures which persisted beyond the time of detectable blood alcohol levels. 4. Blood sugar rose by a similar amount after alcohol and the isocaloric glucose control drink, but peak plasma insulin levels were higher after the control drink. 5. Plasma sodium rose in keeping with alcohol induced water diuresis. No significant changes in plasma potassium or magnesium were seen after alcohol. 6. Compared with the control drink there was no evidence from measurements of circulating adrenaline, noradrenaline, cortisol, aldosterone or renin of activation of the sympathoadrenal axis, adrenal cortex or renin-angiotensin systems after alcohol.