Subclinical hyperthyroidism and atrial fibrillation
Subclinical hyperthyroidism and atrial fibrillation
复制标题
DOI：
10.1089/105072502760143881
复制
发表时间：
2002-06-01
期刊：
影响因子：
6.6
通讯作者：
Sawin, CT
中科院分区：
文献类型：
--
作者：
Sawin, CT
亚临床甲状腺功能亢进症的特点是血清促甲状腺激素（TSH）浓度明显降低，且无明显的甲状腺功能亢进症状。是否所有血清TSH值低的人都可以被认为是亚临床甲状腺功能亢进还不确定，但低血清TSH本身是房颤和其他心血管疾病的危险因素。筛查所有人，即使在老年组中，亚临床甲状腺功能亢进症本身可能是不合理的，但这些人可能会筛查亚临床甲状腺功能减退症，从而识别出亚临床甲状腺功能亢进症。没有对照试验显示亚临床甲状腺功能亢进症的治疗益处，因此目前的治疗需要通过临床判断来确定，通过监测患者以观察低血清TSH水平是否持续并评估是否存在治疗的其他决定因素，如血清三碘甲腺原氨酸（T-3）浓度升高，多结节性甲状腺肿或明显症状的出现。
Subclinical hyperthyroidism is characterized by a clearly low serum concentration of thyrotropin (TSH) and the absence of obvious symptoms of hyperthyroidism. Whether or not all persons with a low value for serum TSH can be considered subclinically hyperthyroid is uncertain, but the low serum TSH per se is a risk factor for atrial fibrillation and perhaps other cardiovascular disease. Screening all persons, even in the older age groups, for subclinical hyperthyroidism may not be justified in and of itself but such persons would likely be screened for subclinical hypothyroidism and so those with subclinical hyperthyroidism identified. There are no controlled trials that show the benefit of treatment of subclinical hyperthyroidism, thus therapy at present needs to be determined by clinical judgement, aided by monitoring the patient to see if the low serum TSH level persists and assessing the presence or absence of other determinants of therapy such as an elevated serum triiodothyronine (T-3) concentration, a multinodular goiter, or the appearance of overt symptoms.