Cytochrome P450-catalyzed oxidation of halobenzene derivatives
Cytochrome P450-catalyzed oxidation of halobenzene derivatives
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DOI：
10.1021/tx9601061
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发表时间：
1997-06-01
影响因子：
4.1
通讯作者：
vanBladeren, PJ
中科院分区：
文献类型：
--
作者：
Rietjens, IMCM;denBesten, C;vanBladeren, PJ
毒理学领域的主要目标之一是阐明异生物质在生物体中产生有害生物反应的机制。大量外源物质本身具有生物惰性，其许多毒理学作用是通过形成“活性”代谢物来介导的。了解化学物质代谢成反应产物的不同途径可以增加我们对异生物质化学结构与其对生命系统影响之间关系的理解。此外，这些知识将有助于识别给定分子中的化学基团，这些化学基团使该分子容易经历一系列可能最终导致毒性的过程。
One of the major goals in the field of toxicology is to elucidate the mechanisms by which xenobiotics produce detrimental biological responses in organisms. A large number of xenobiotics are as such biologically inert, and many of their toxicological effects are mediated through the formation of ‘active’metabolites. Knowledge on the different pathways by which a chemical can be metabolized into reactive products increases our understanding of the relationship between the chemical structure of xenobiotics and their effects on living systems. Moreover, such knowledge will be helpful in identifying chemical groupings in a given molecule, which predispose that molecule to a sequence of processes that might eventually lead to toxicity.