Asymmetric catalysis of intramolecular N-H insertion reactions of alpha-diazocarbonyls
Asymmetric catalysis of intramolecular N-H insertion reactions of alpha-diazocarbonyls
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DOI：
10.1039/cc9960001465
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发表时间：
1996-06-21
影响因子：
4.9
通讯作者：
Ye, T
中科院分区：
文献类型：
--
作者：
Garcia, CF;McKervey, MA;Ye, T
α-重氮羰基底物的分子内N-H插入反应由羧酸铑（II）催化，具有与C-H插入和β-消除的催化剂依赖性竞争;使用手性催化剂实现了导致ee高达45%的哌啶酸衍生物的不对称N-H插入。
Intramolecular N-H insertion reactions of alpha-diazocarbonyl substrates are catalysed by rhodium(II) carboxylates with catalyst-dependent competition with C-H insertion and beta-elimination; asymmetric N-H insertion leading to a pipecolic acid derivative with ee up to 45% is achieved using chiral catalysts.