Risk factors for second urinary tract infection among college women
Risk factors for second urinary tract infection among college women
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DOI：
10.1093/oxfordjournals.aje.a010170
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发表时间：
2000-06-15
影响因子：
5
通讯作者：
Marrs, CF
中科院分区：
文献类型：
--
作者：
Foxman, B;Gillespie, B;Marrs, CF
为了更好地了解复发性尿路感染（UTI）的病因，作者对285名首次UTI的女大学生进行了为期6个月或直至第二次UTI的随访。第一次UTI由于大肠杆菌其次是第二次UTI的三倍以上，比非大肠杆菌。大肠杆菌首次UTI（24 vs. 8%; p = 0.02）。对1992年9月至1994年12月密歇根大学卫生服务中心和德克萨斯大学奥斯汀分校卫生服务中心的224名妇女进行了Logistic回归分析，首次UTI是由E.大肠杆菌，阴道性交增加了第二次UTI的风险，（比值比（OR）= 1.60，95%置信区间（CI）：1.19，2.15），（OR = 1.37，95% CI：0.91，2.07）尿路病原体，与使用子宫帽、宫颈帽和/或杀精剂一样（同一泌尿系病原体：OR = 1.53，95% CI：0.95，2.47;不同泌尿系病原体：OR = 1.77，95% CI：1.22，2.58）。使用安全套可降低由不同泌尿系病原体引起的第二次UTI的风险（OR = 0.68，95% CI：0.48，0.99），但对由同一种大肠杆菌引起的第二次UTI无影响。大肠埃希菌（OR = 0.99，95%CI：0.66，1.50）。治疗类型或持续时间与第二次UTI无关。虽然第二次UTI的风险受到性行为的强烈影响，但由E。大肠杆菌感染者比非大肠杆菌感染者更容易在6个月内发生第二次UTI。
To better understand the etiology of recurrent urinary tract infection (UTI), the authors followed a cohort of 285 female college students with first UTI for 6 months or until second UTI. A first UTI due to Escherichia coli was followed by a second UTI three times more often than was a non-E. coli first UTI (24 vs. 8%; p = 0.02). In a logistic regression analysis limited to the 224 women from the University of Michigan Health Service and the University of Texas at Austin Health Service from September 1992 to December 1994, with a first UTI due to E. coli, vaginal intercourse increased the risk of a second UTI with both a different (odds ratio (OR) = 1.60, 95% confidence interval (CI): 1.19, 2.15) and the same (OR = 1.37, 95% CI: 0.91, 2.07) uropathogen, as did using a diaphragm, cervical cap, and/or spermicide (same uropathogen: OR = 1.53, 95% CI: 0.95, 2.47; different uropathogen: OR = 1.77, 95% CI: 1.22, 2.58). Condom use decreased the risk of a second UTI caused by a different uropathogen (OR = 0.68, 95% CI: 0.48, 0.99) but had no effect on a second UTI caused by the same E. coli (OR = 0.99; 95% CI: 0.66, 1.50). Type or duration of treatment was not associated with a second UTI. Although the risk of second UTI is strongly influenced by sexual behavior, women with a first UTI caused by E. coli are more likely than are those with a non-E, coli first UTI to have a second UTI within 6 months.