Treatment‐resistant schizophrenia in patients with 3q29 deletion: A case series of four patients
Treatment‐resistant schizophrenia in patients with 3q29 deletion: A case series of four patients
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3q29 缺失患者的难治性精神分裂症：四名患者的病例系列
DOI：
10.1111/pcn.13361
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发表时间：
2022
影响因子：
11.9
通讯作者：
Ozaki Norio
中科院分区：
文献类型：
--
作者：
Nawa Yoshihiro;Kushima Itaru;Aleksic Branko;Yamamoto Maeri;Kimura Hiroyuki;Banno Masahiro;Hashimoto Ryota;Ozaki Norio
另一名3q29缺失的SCZ患者也被报道为治疗耐药。由于D2受体拮抗剂无效，中边缘多巴胺通路中的高多巴胺能状态可能在3q29缺失相关精神病中不起关键作用。3q29缺失是精神分裂症（SCZ） 1的最强危险因素之一（优势比bbb40），并与其他精神疾病相关，包括智力残疾（ID）、自闭症谱系障碍和双相情感障碍。然而，这些患者的精神病学表现和治疗反应的细节尚未被描述。CPZ,氯丙嗪;脑电图、脑电描记法;身份证，智力残疾；IQ，智商；MRI，磁共振成像；无，不可用；SCZ,精神分裂症。患者1,55岁女性，出生时体重过低。3q29缺失患者的难治性精神分裂症：4例患者的病例系列《精神病学与临床神经科学》版权归Wiley-Blackwell所有，未经版权所有者明确书面许可，其内容不得复制或通过电子邮件发送到多个网站或发布到listserv。但是，用户可以打印、下载或通过电子邮件发送文章供个人使用。这篇摘要可以删节。对副本的准确性不作任何保证。用户应参考资料的原始出版版本以获取完整摘要。版权适用于所有摘要。
Another SCZ patient with 3q29 deletion was also reported to be treatment resistant. 5 As D2 receptor antagonists were not effective, a hyperdopaminergic state in the mesolimbic dopamine pathways may not play a crucial role in 3q29 deletion-associated psychosis. The 3q29 deletion is one of the strongest risk factors (odds ratio > 40) for schizophrenia (SCZ) 1 and is associated with other psychiatric disorders including intellectual disability (ID), autism spectrum disorder, and bipolar disorder. 2 However, details of psychiatric manifestations and treatment responses have not been described in these patients. CPZ, chlorpromazine; EEG, electroencephalography; ID, intellectual disability; IQ, intelligence quotient; MRI, magnetic resonance imaging; N/A, not available; SCZ, schizophrenia. gl Patient 1, a 55-year-old female, was born with low birth weight. Treatment-resistant schizophrenia in patients with 3q29 deletion: A case series of four patients.[Extracted from the article]Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.
DOI：
--
发表时间：
1998
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
A. Leonard;M. Davare;M. C. Horne;C. C. Garner-C.;J. W. Hell
通讯作者：
A. Leonard;M. Davare;M. C. Horne;C. C. Garner-C.;J. W. Hell