Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions
Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions
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DOI：
10.1158/0008-5472.can-05-4183
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发表时间：
2006-04-15
期刊：
影响因子：
11.2
通讯作者：
Frisch, SM
中科院分区：
文献类型：
--
作者：
Helfer, B;Boswell, BC;Frisch, SM
在正常和某些肿瘤细胞中发现了显著的caspase-8活性，这表明caspase-8具有可能有助于肿瘤进展的替代性非凋亡功能。在这篇文章中，我们报告caspase-8促进细胞运动。特别是，半胱天冬酶-8需要的钙蛋白酶，Rac，和lamellipodial组装的最佳激活。这代表了caspase-8的一种新的非凋亡功能，作用于caspase-8和钙蛋白酶蛋白水解途径的交叉点，以协调细胞死亡与细胞运动信号。
Significant caspase-8 activity has been found in normal and certain tumor cells, suggesting that caspase-8 possesses an alternative, nonapoptotic function that may contribute to tumor progression. In this article, we report that caspase-8 promotes cell motility. In particular, caspase-8 is required for the optimal activation of calpains, Rac, and lamellipodial assembly. This represents a novel nonapoptotic function of caspase-8 acting at the intersection of the caspase-8 and calpain proteolytic pathways to coordinate cell death versus cell motility signaling.