Encoding of Probabilistic Rewarding and Aversive Events by Pallidal and Nigral Neurons
Encoding of Probabilistic Rewarding and Aversive Events by Pallidal and Nigral Neurons
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DOI：
10.1152/jn.90764.2008
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发表时间：
2009-02-01
影响因子：
2.5
通讯作者：
Bergman, Hagai
中科院分区：
文献类型：
--
作者：
Joshua, Mati;Adler, Avital;Bergman, Hagai
Joshua M、Adler A、Rosin B、Vaadia E、Bergman H。苍白球和黑质神经元对概率奖励和厌恶事件的编码。 《神经生理学杂志》101：758-772，2009 年。首次发表于 2008 年 12 月 3 日； doi：10.1152/jn.90764.2008。先前的研究很少测试基底神经节（BG）的高频放电（HFD）神经元的活动是否受到厌恶事件的预期、传递和遗漏的调节。因此BG网络编码的完整值域仍然未知。我们研究了两只猴子在经典条件反射任务中苍白球外节（GPe，n = 310）、内节（GPi，n = 149）和黑质网状部（SNr，n = 145）的 HFD 神经元的活动，其中线索预测食物、中性或吹气结果的概率。 BG HFD 神经元的反应是持久且多样化的，放电率同时增加和减少。人群对奖励相关事件的反应大于对厌恶和中性相关事件的反应。除了对实际吹气输送的反应之外，后面的反应是相似的。对于与奖励相关的事件，响应细胞的比例更大，在放电率增加而不是减少的响应中，可以更好地区分奖励性和厌恶性试验。与厌恶相关事件相比，GPe 和 GPi 单个单元受到更强烈的调节，并且更好地反映了奖励相关事件的概率。 SNr 神经元对奖励事件的编码的偏见较小，尤其是在结果时期。最后，SNr 对所有预测线索的反应潜伏期都比苍白球反应的潜伏期短。这些结果表明，与厌恶事件相比，奖励会优先激活 BG HFD 神经元。
Joshua M, Adler A, Rosin B, Vaadia E, Bergman H. Encoding of probabilistic rewarding and aversive events by pallidal and nigral neurons. J Neurophysiol 101: 758-772, 2009. First published December 3, 2008; doi:10.1152/jn.90764.2008. Previous studies have rarely tested whether the activity of high-frequency discharge (HFD) neurons of the basal ganglia (BG) is modulated by expectation, delivery, and omission of aversive events. Therefore the full value domain encoded by the BG network is still unknown. We studied the activity of HFD neurons of the globus pallidus external segment (GPe, n = 310), internal segment (GPi, n = 149), and substantia nigra pars reticulata (SNr, n = 145) in two monkeys during a classical conditioning task with cues predicting the probability of food, neutral, or airpuff outcomes. The responses of BG HFD neurons were long-lasting and diverse with coincident increases and decreases in discharge rate. The population responses to reward-related events were larger than the responses to aversive and neutral- related events. The latter responses were similar, except for the responses to actual airpuff delivery. The fraction of responding cells was larger for reward-related events, with better discrimination between rewarding and aversive trials in the responses with an increase rather than a decrease in discharge rate. GPe and GPi single units were more strongly modulated and better reflected the probability of reward-than aversive-related events. SNr neurons were less biased toward the encoding of the rewarding events, especially during the outcome epoch. Finally, the latency of SNr responses to all predictive cues was shorter than the latency of pallidal responses. These results suggest preferential activation of the BG HFD neurons by rewarding compared with aversive events.