Polyketides produced by Daldinia loculata cultured from Northern Manitoba
Polyketides produced by Daldinia loculata cultured from Northern Manitoba
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DOI：
10.1016/j.tetlet.2011.01.150
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发表时间：
2011-04-06
影响因子：
1.8
通讯作者：
Sorensen, John L.
中科院分区：
文献类型：
--
作者：
Nadeau, Amy K.;Sorensen, John L.
培养存在于从北方马尼托巴收集的土壤样品中的真菌。分离并鉴定了该菌产生的天然产物聚酮化合物（1）、（2）、（3）。还分离出痕量的芳香醇酪醇（4）。通过对核核糖体DNA的内转录间隔区进行测序，将该生物体鉴定为Daldinia loculata。测定了聚酮化合物1-3的抗大肠杆菌活性。大肠杆菌，观察到1显示出温和的抗菌活性。(c)2011爱思唯尔有限公司版权所有。
The fungus present in a soil sample collected from Northern Manitoba was cultured. The natural products produced by this organism were isolated and identified as the polyketides (1), (2), (3). A trace amount of the aromatic alcohol tyrosol (4) was also isolated. This organism was identified as Daldinia loculata by sequencing of the internally transcribed spacer region of the nuclear ribosomal DNA. The polyketides 1-3 were assayed against E. coli and it was observed that 1 displayed mild antibiotic activity. (c) 2011 Elsevier Ltd. All rights reserved.