Lenticular levels of amino acids and free UV filters differ significantly between normals and cataract patients.
Lenticular levels of amino acids and free UV filters differ significantly between normals and cataract patients.
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正常人和白内障患者的晶状体氨基酸和游离紫外线过滤剂水平存在显着差异。
DOI：
10.1167/iovs.04-0178
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Truscott,RogerJW
中科院分区：
文献类型：
--
作者：
Streete,IslaM;Jamie,JoanneF;Truscott,RogerJW
目的。与正常镜片相比，确定白内障镜片中游离紫外线过滤剂和选定氨基酸的含量。通过 HPLC 检查印度白内障晶状体 (n= 39) 和正常晶状体 (n= 6)，以量化紫外线过滤化合物、紫外线过滤前体氨基酸色氨酸 (Trp) 以及酪氨酸 (Tyr) 和尿酸的水平。结果。白内障晶状体中两种主要的灵长类紫外线过滤剂，3-羟基犬尿氨酸葡萄糖苷（3OHKG）和4-（2-氨基-3-羟基苯基）-4-氧代丁酸葡萄糖苷（AHBG）的水平与正常晶状体中的水平相比显着降低。相比之下，色氨酸的水平大大增加。平均色氨酸浓度比正常晶状体高一个数量级，86% 的深色白内障晶状体核的色氨酸浓度高于正常晶状体的平均水平。白内障晶状体中酪氨酸的浓度也较高。然而，Kyn 水平没有变化，尿酸水平显着降低。结论。与正常镜片相比，白内障镜片中游离紫外线过滤化合物 3OHKG 和 AHBG 以及色氨酸、酪氨酸和尿酸的水平有所不同。这些数据表明，很大一部分白内障患者的新陈代谢可能与拥有正常晶状体的人有很大不同。尽管这种代谢缺陷的机制尚不清楚，但作者推测白内障患者的氨基酸转运系统可能上调。由于白内障中的犬尿氨酸水平与正常晶状体的水平没有显着差异，因此在将犬尿氨酸转化为 3OHKG 的步骤中的一个或两个步骤中，晶状体紫外线过滤器路径可能存在缺陷。
purpose. To determine the levels of free UV filters and selected amino acids in cataract lenses compared with normal lenses.methods. Indian cataract lenses (n= 39) and normal lenses (n= 6) were examined by HPLC to quantify levels of UV filter compounds, the UV filter precursor amino acid tryptophan (Trp), as well as tyrosine (Tyr) and uric acid.results. The levels of the two major primate UV filters, 3-hydroxykynurenine glucoside (3OHKG) and 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid glucoside (AHBG), in cataract lenses were markedly decreased compared with levels in normal lenses. By contrast, the levels of Trp were greatly increased. Mean Trp concentrations were an order of magnitude higher than in normal lenses, with 86% of dark-colored cataract lens nuclei having Trp concentrations greater than the mean level in the normal lenses. The concentrations of Tyr were also higher in cataract lenses. The levels of Kyn, however, were unchanged, and the uric acid levels were substantially lower.conclusions. The levels of the free UV filter compounds 3OHKG and AHBG, and also of Trp, Tyr, and uric acid were different in cataract lenses compared to normal lenses. These data suggest that the metabolism of a large proportion of patients with cataract may be substantially different than in persons with normal lenses. Although the mechanism of such metabolic defects are unknown, the authors speculate that an amino acid transporter system may be upregulated in patients with cataract. Because kynurenine levels in cataract were not significantly different from those of normal lenses, there may be a defect in the lenticular UV filter pathway at one, or both, of the steps that convert kynurenine to 3OHKG.
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