Effects of vanillin on potassium bromate-induced neurotoxicity in adult mice: impact on behavior, oxidative stress, genes expression, inflammation and fatty acid composition
Effects of vanillin on potassium bromate-induced neurotoxicity in adult mice: impact on behavior, oxidative stress, genes expression, inflammation and fatty acid composition
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DOI：
10.1080/13813455.2017.1283527
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发表时间：
2017-01-01
影响因子：
3
通讯作者：
Ben Amara, Ibtissem
中科院分区：
文献类型：
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作者：
Ben Saad, Hajer;Kharrat, Nadia;Ben Amara, Ibtissem
背景：已知香兰素具有重要的抗氧化活性。目的：本研究旨在确定香草醛对溴酸钾（KBrO3）诱导的小鼠抑郁样行为和氧化应激的治疗效果。材料和方法：小鼠在 15 天内接触溴酸钾 (KBrO3)、KBrO3+ 香草醛或仅接触香草醛。结果：我们的结果显示，经 KBrO3 处理的小鼠的脂肪酸组成发生了显着变化。此外，KBrO3 还导致酶活性和基因表达、Na+ -K+ 和 Mg2+ -ATP 酶、乙酰胆碱酯酶和丁基胆碱酯酶活性显着降低。 KBrO3治疗组大脑中肿瘤坏死因子-α、白细胞介素1β、白细胞介素6和COX2的基因表达显着增加。组织病理学观察与这些效应一致。与香草醛共同治疗可显着减轻 KBrO3 诱导的氧化应激和炎症。结论：这项工作表明香草醛可以减轻 KBrO3 诱导的抑郁症，并且这种神经保护作用是通过抗氧化和抗炎活性发挥作用的。
Context: Vanillin is known to possess important antioxidant activity. Objective: The current study was conducted to establish the therapeutic efficiency of vanillin against potassium bromate (KBrO3)-induced depression-like behavior and oxidative stress in mice. Material and methods: Mice were exposed during 15 days either to potassium bromate (KBrO3), KBrO3+ vanillin or to only vanillin. Results: Our results revealed a significant modification in the fatty acid composition of the KBrO3-treated mice. In addition, KBrO3 induced a significant reduction in enzymatic activities and gene expressions, Na+ -K+ and Mg2+ -ATPases, acetylcholinesterase and butylcholinesterase activities. The gene expression of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and COX2, significantly increased in the cerebrum of KBrO3-treated group. Histopathological observations were consistent with these effects. Co-treatment with vanillin significantly attenuated KBrO3-induced oxidative stress and inflammation. Conclusion: This work suggests that vanillin mitigates KBrO3-induced depression, and that this neuroprotective effect proceeds through anti-oxidant and anti-inflammatory activities.