Clinical evaluation of the i-STAT kaolin activated clotting time (ACT) test in different clinical settings in a large academic urban medical center: comparison with the Medtronic ACT Plus.
Clinical evaluation of the i-STAT kaolin activated clotting time (ACT) test in different clinical settings in a large academic urban medical center: comparison with the Medtronic ACT Plus.
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i-STAT 高岭土活化凝血时间 (ACT) 测试在大型学术城市医疗中心不同临床环境下的临床评估：与美敦力 ACT Plus 的比较。
DOI：
10.1309/ajcpsf8asgonnqm6
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发表时间：
2011
影响因子：
3.5
通讯作者：
K. Lewandrowski
中科院分区：
文献类型：
--
作者：
E. Lewandrowski;ElizabethM Van Cott;K. Gregory;I. Jang;K. Lewandrowski
从历史上看，医院很难改变活化凝血时间(ACT)的测试方法，因为不同仪器获得的ACT值不同，不同程序使用的靶点范围有很大差异，以及在重症监护情况下在床边进行交叉研究存在困难。I-STAT(雅培护理中心，新泽西州普林斯顿)高岭土ACT与美敦力ACT Plus(明尼阿波利斯美敦力)的比较数据有限。I-STAT系统除了可以测试一些重症监护分析物外，还可以执行ACT测试，并可能提供比其他ACT分析仪更多的潜在优势。对121个同时进行的分裂样本测试的ACT值进行比较，R(2)为0.88，I-STAT=0.79美敦力+72.0。皮尔逊相关系数R=0.94，表明两种方法之间有统计学意义的相关性。基于这一比较，我们能够在我们整个机构实施i-stat ACT，而不改变任何单个程序的目标范围。
Historically, it has been difficult for hospitals to change methods for activated clotting time (ACT) testing because of differences in ACT values obtained with different instruments, wide differences in target ranges used in different procedures, and the difficulty of performing crossover studies at the bedside in critical care situations. There are limited published data comparing the i-STAT (Abbott Point of Care, Princeton, NJ) kaolin ACT with the Medtronic ACT Plus (Medtronic, Minneapolis, MN). The i-STAT system can perform ACT testing in addition to testing of a number of critical care analytes and may offer potential advantages over other ACT analyzers. Comparison of ACT values on 121 simultaneous split-sample tests yielded an R(2) of 0.88 with i-STAT = 0.79 Medtronic + 72.0. The Pearson correlation was R = 0.94, indicating statistically significant correlation between the 2 methods. Based on this comparison, we were able to implement the i-STAT ACT throughout our institution without changing target ranges for any individual procedure.