LEUKOKINETIC STUDIES .4. TOTAL BLOOD, CIRCULATING AND MARGINAL GRANULOCYTE POOLS AND GRANULOCYTE TURNOVER RATE IN NORMAL SUBJECTS
LEUKOKINETIC STUDIES .4. TOTAL BLOOD, CIRCULATING AND MARGINAL GRANULOCYTE POOLS AND GRANULOCYTE TURNOVER RATE IN NORMAL SUBJECTS
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DOI：
10.1172/jci104338
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发表时间：
1961-01-01
影响因子：
15.9
通讯作者：
RAAB, SO
中科院分区：
文献类型：
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作者：
ATHENS, JW;WINTROBE, MM;RAAB, SO
已在 70 名正常男性受试者中测量了总血液粒细胞池 (TBGP) 及其两个亚室、循环粒细胞池 (CGP) 和边缘粒细胞池 (MGP) 的大小。此外，还测定了其中 45 名受试者的血液中粒细胞的半衰期 (T 1/2) 和每日粒细胞周转率 (GTR)。平均值±1 SD，以每公斤体重的细胞数 X 107 表示，为 TBGP，65.0±22.4； CGP，31.7 [正负] 11.1； MGP，33.3 [正负] 16.0。平均 T 1/2 为 6.6±1.16 小时，GTR 为每天每公斤体重 179.9±74.3 X 107 个粒细胞。急性体育锻炼和肾上腺素输注使细胞从 MGP 转移到 CGP，但没有改变 TBGP 的大小，也没有改变 GTR。口服泼尼松 11 天导致 TBGP 增大，MGP 和 CGP 也成比例增大。在这个新的血液粒细胞水平上，建立了具有正常 GTR 的稳定状态。静脉注射细菌内毒素导致细胞从 CGP 转移到 MGP，并且来自骨髓粒细胞库的细胞流入导致 TBGP 大小增加。
The size of the total blood granulocyte pool (TBGP) and its two subcompartments, the circulating granulocyte pool (CGP) and marginal granulocyte pool (MGP) have been measured in 70 normal male subjects. In addition, the half-time disappearance (T 1/2) of granulocytes from the blood and the daily granulocyte turnover rate (GTR) were determined in 45 of these subjects. The mean values [plus or minus] 1 SD, expressed as number of cells X 107 per kg of body weight were TBGP, 65.0 [plus or minus] 22.4; CGP, 31.7 [plus or minus] 11.1; MGP, 33.3 [plus or minus] 16.0. The mean T 1/2 was 6.6 [plus or minus] 1.16 hours and the GTR was 179.9 [plus or minus] 74.3 X 107 granulocytes per kg of body weight per day. Acute physical exercise and epinephrine infusion produced a shift of cells from the MGP to the CGP but did not change the size of the TBGP nor alter the GTR. Oral prednisone given for 11 days resulted in an increase in size of the TBGP with both the MGP and CGP increasing proportionally. At this new blood granulocyte level a steady state was established with a normal GTR. Intravenous bacterial endotoxin injection produced a shift of cells from the CGP to the MGP and an influx of cells from the bone marrow granulocyte pool resulted in an increase in the size of the TBGP.