Practical Synthesis of Polymethylated Flavones: Nobiletin and Its Desmethyl Derivatives
Practical Synthesis of Polymethylated Flavones: Nobiletin and Its Desmethyl Derivatives
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DOI：
10.1021/acs.oprd.9b00091
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发表时间：
2019-04-01
影响因子：
3.4
通讯作者：
Kan, Toshiyuki
中科院分区：
文献类型：
--
作者：
Asakawa, Tomohiro;Sagara, Hiroto;Kan, Toshiyuki
我们提出了一种实用的合成多甲氧基化柑橘黄酮皂荚素，适合在百克规模上使用。该化合物及其衍生物的可用性将有助于对其生物活性进行详细的化学生物学研究，包括通过cAMP依赖性蛋白激酶A/细胞外信号相关蛋白激酶/cAMP反应元件结合蛋白途径激活信号。
We present a practical synthesis of the polymethoxylated citrus flavone nobiletin that is suitable for use on a hundred gram scale. Ready availability of this compound and its derivatives will aid detailed chemical-biological investigations of their biological activities, including activation of signaling via the cAMP-dependent protein kinase A/extracellular signal-related protein kinase/cAMP response element-binding protein pathway.