The bile acid synthesis pathway is present and functional in the human ovary.
The bile acid synthesis pathway is present and functional in the human ovary.
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DOI：
10.1371/journal.pone.0007333
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发表时间：
2009-10-06
期刊：
影响因子：
3.7
通讯作者：
Usheva A
中科院分区：
文献类型：
--
作者：
Smith LP;Nierstenhoefer M;Yoo SW;Penzias AS;Tobiasch E;Usheva A
胆汁酸是胆固醇消除途径的终产物，是膳食脂质和脂溶性维生素吸收所必需的，并维持肝脏中胆固醇合成和胆固醇排泄之间的平衡。它们由类固醇结构组成，主要在肝脏中通过胆固醇的氧化产生。胆固醇在人类卵泡中也非常丰富，在那里它被用于形成性类固醇。在这里，我们描述的第一次证据表明，胆汁酸合成途径的各个方面都存在于人类卵泡，包括在经典和替代途径的酶，已知的核受体调节途径，和最终产品胆汁酸。此外，我们提供的功能证据表明，胆汁酸是由人卵泡颗粒细胞在响应胆固醇存在的培养基。这些发现建立了一个新的途径，目前在人类卵巢卵泡，有能力直接竞争性类固醇的合成。
Bile acids, end products of the pathway for cholesterol elimination, are required for dietary lipid and fat-soluble vitamin absorption and maintain the balance between cholesterol synthesis in the liver and cholesterol excretion. They are composed of a steroid structure and are primarily made in the liver by the oxidation of cholesterol. Cholesterol is also highly abundant in the human ovarian follicle, where it is used in the formation of the sex steroids. Here we describe for the first time evidence that all aspects of the bile acid synthesis pathway are present in the human ovarian follicle, including the enzymes in both the classical and alternative pathways, the nuclear receptors known to regulate the pathway, and the end product bile acids. Furthermore, we provide functional evidence that bile acids are produced by the human follicular granulosa cells in response to cholesterol presence in the culture media. These findings establish a novel pathway present in the human ovarian follicle that has the capacity to compete directly with sex steroid synthesis.
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影响因子：
10.5
作者：
Duggavathi, Rajesha;Volle, David H.;Schoonjans, Kristina
通讯作者：
Schoonjans, Kristina
影响因子：
9.8
作者：
Nguyen, LB;Xu, GR;Salen, G
通讯作者：
Salen, G
影响因子：
--
作者：
Torchia, Enrique C.;Stolz, Andrew;Agellon, Luis B.
通讯作者：
Agellon, Luis B.
DOI：
10.1016/j.jsbmb.2007.05.001
发表时间：
2007-08-01
影响因子：
4.1
作者：
Mendelson, Carole R.;Kamat, Amrita
通讯作者：
Kamat, Amrita
影响因子：
10.6
作者：
Hasler, Julia A.;Estabrook, Ronald;Beaune, Philippe
通讯作者：
Beaune, Philippe