The severity of periodontal disease is associated with the development of glucose intolerance in non-diabetics: The Hisayama study
The severity of periodontal disease is associated with the development of glucose intolerance in non-diabetics: The Hisayama study
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DOI：
10.1177/154405910408300610
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发表时间：
2004-06-01
影响因子：
7.6
通讯作者：
Koga, T
中科院分区：
文献类型：
--
作者：
Saito, T;Shimazaki, Y;Koga, T
炎症被假设在2型糖尿病的发展中起重要作用;然而，关于临床炎症状况的报道有限。研究表明，牙周炎会影响糖尿病患者的血糖控制。这项以社区为基础的研究探讨了牙周炎和糖耐量状态之间的关系，包括状态的变化。1998年对961名成年人进行了75克口服葡萄糖耐量试验，研究牙周状况与试验结果之间的关系。与浅囊袋（< 1.3 mm）相比，深囊袋（平均囊袋深度> 2.0 mm）与糖耐量受损和糖尿病显著相关。在10年前葡萄糖耐量正常的亚组中，随后发生葡萄糖耐量受损的受试者更可能有深口袋。深囊袋与当前糖耐量状态和糖耐量异常的发生密切相关。
Inflammation is hypothesized to play a significant role in the development of type 2 diabetes; however, reports on clinical inflammatory conditions are limited. Studies have suggested that periodontitis affects glucose control in diabetics. This community- based study examined the relationship between periodontitis and glucose tolerance status, including changes in status. The relationship between periodontal condition and the results of a 75-g oral glucose tolerance test was examined in 961 adults in 1998. Deep pockets ( mean pocket depth > 2.0 mm) were significantly associated with impaired glucose tolerance and with diabetes as compared with shallow pockets (< 1.3 mm). In the subgroup with normal glucose tolerance 10 years previously, subjects who subsequently developed impaired glucose tolerance were significantly more likely to have deep pockets. Deep pockets were closely related to current glucose tolerance status and the development of glucose intolerance.