Interleukin-1B polymorphisms and gastric cancer risk - A meta-analysis
Interleukin-1B polymorphisms and gastric cancer risk - A meta-analysis
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DOI：
10.1158/1055-9965.epi-06-0267
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发表时间：
2006-10-01
影响因子：
3.8
通讯作者：
Rabkin, Charles S.
中科院分区：
文献类型：
--
作者：
Kamangar, Farin;Cheng, Cindy;Rabkin, Charles S.
有研究报道白细胞介素-1B（IL-1B）和IL-1受体拮抗剂（IL-1 RN）基因的促炎性多态性与胃癌风险增加相关。然而，其他研究显示零或反向关联。该荟萃分析回顾并总结了这些关联的已发表证据。检索PubMed数据库，获得了35项关于IL-1B-511 C > T、IL-1B-31 T > C或IL-1 RN可变数目串联重复序列多态性与胃癌风险之间相关性的研究。计算Q统计量和12统计量以检查异质性。使用DerSimonian-Laird方法在随机效应模型中计算总结优势比（OR）和95%置信区间（95% CI）。对于所有胃癌，IL-1B-511 CT与CC和TT与CC基因型的总体OR（95% CI）分别为1.07（0.91-1.25）和1.16（0.95-1.42）。IL-1B-31 CT与TT和CC与TT基因型之间的相关性OR（95% CI）分别为0.99（0.83-1.19）和0.98（0.78-1.21）。对于IL-1 RN与胃癌的关系，*2/L与LL和 *2/*2与L/L的OR（95%CI）分别为1.15（0.96-1.38）和1.23（0.79-1.92）。对于每一个检查的关联，研究之间存在显著的异质性; P-异质性
Some studies have reported that proinflammatory polymorphisms in interleukin-1B (IL-1B) and IL-1 receptor antagonist (IL-1RN) genes are associated with increased gastric cancer risk. However, other studies have shown null or inverse associations. This meta-analysis reviews and summarizes published evidence for these associations. Searching the PubMed Database yielded 35 studies that reported on the association between IL-1B -511 C > T, IL-1B -31 T > C, or IL-1RN variable number tandem repeat polymorphisms and gastric cancer risk. Q-statistics and 12 statistics were calculated to examine heterogeneity. Summary odds ratios (OR) and 95% confidence intervals (95% CI) were calculated in the random-effects model using the DerSimonian-Laird method. For all gastric cancers, the overall ORs (95% CIs) for IL-1B -511 CT versus CC and TT versus CC genotypes were 1.07 (0.91-1.25) and 1.16 (0.95-1.42), respectively. ORs (95% CIs) for the association between IL-1B -31 CT versus TT and CC versus TT genotypes were 0.99 (0.83-1.19) and 0.98 (0.78-1.21), respectively. For the associations between IL-1RN and gastric cancer, ORs (95% CIs) for *2/L versus LL and *2/*2 versus L/L were 1.15 (0.96-1.38) and 1.23 (0.79-1.92). For each of the examined associations, there was significant heterogeneity among studies; P-heterogeneity