HYPERTHERMIC EFFECTS ON DNA-REPAIR MECHANISMS
HYPERTHERMIC EFFECTS ON DNA-REPAIR MECHANISMS
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DOI：
10.1148/123.2.475
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发表时间：
1977-01-01
期刊：
影响因子：
19.7
通讯作者：
GETZ, S
中科院分区：
文献类型：
--
作者：
CORRY, PM;ROBINSON, S;GETZ, S
使用中性和碱性蔗糖密度梯度进行了研究，以调查 41°-43°的影响。 C关于中国仓鼠卵巢细胞修复因暴露于电离辐射而引起的单链DNA断裂(SSB)和双链DNA断裂(DSB)的能力。当照射前存在高热时，会发生显着的抑制。这些数据支持这样的结论：未修复的 DNA 损伤可能对细胞是致命的。虽然热疗后没有观察到辐射引起的 DSB 频率增加，但观察到 SSB 频率增加了 10-20%。 [这项研究是癌症治疗的模型。]。
Studies were done using neutral and alkaline sucrose density gradients to investigate the effect of 41.degree.-43.degree. C on the ability of Chinese hamster ovary cells to repair single (SSB) and double stranded DNA breaks (DSB) caused by exposure to ionizing radiation. When hyperthermia exists prior to irradiation significant inhibition occurs. The data support the conclusion that unrepaired DNA damage may be lethal to the cell. Though no increase in radiation induced DSB frequency was observed subsequent to hyperthermia, a 10-20% increase in SSB frequency was observed. [This study is a model for cancer treatment.].