INHALATION TOXICITY STUDIES ON CIGARETTE-SMOKE .2. TOBACCO-SMOKE INHALATION DOSIMETRY STUDIES ON SMALL LABORATORY-ANIMALS
INHALATION TOXICITY STUDIES ON CIGARETTE-SMOKE .2. TOBACCO-SMOKE INHALATION DOSIMETRY STUDIES ON SMALL LABORATORY-ANIMALS
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DOI：
10.1016/0300-483x(76)90021-4
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发表时间：
1976-01-01
期刊：
影响因子：
4.5
通讯作者：
LUGTON, WGD
中科院分区：
文献类型：
--
作者：
BINNS, R;BEVEN, JL;LUGTON, WGD
新开发的暴露系统用于对大鼠、小鼠、仓鼠和豚鼠进行烟雾剂量测定研究。在所有物种中，烟雾总颗粒物 (TPM) 大量沉积在下呼吸系统 (LRS) 中，剂量水平范围为 0.515-1.710 mg TPM/g 呼吸组织。所有被检查的物种都发生了烟雾颗粒的鼻沉积。讨论了这些剂量测定数据对于进行烟草烟雾的长期吸入毒性比较研究的重要性。
A newly developed exposure system was used to carry out smoke dosimetry studies on rats, mice, hamsters and guinea pigs. In all species, smoke total particulate matter (TPM) deposited in significant amounts in the lower respiratory system (LRS) at dose levels ranging from 0.515-1.710 mg TPM/g respiratory tissue. Nasal deposition of smoke particulates occurred in all of the species examined. The significance of these dosimetry data in relation to the conduct of long-term comparative inhalation toxicity studies with tobacco smoke is discussed.